Efficient Solvent-Free Solution for 2,4,6-TRI-TERT-BUTYL-N-(TRIMETHYLSILYL)ANILINE Synthesis

2025-3-21

Efficient Solvent-Free Solution for 2,4,6-TRI-TERT-BUTYL-N-(TRIMETHYLSILYL)ANILINE Synthesis: A Comprehensive Guide

This article provides a comprehensive guide to the efficient solvent-free synthesis of 2,4,6-tri-tert-butyl-N-(trimethylsilyl)aniline. It covers various aspects such as product parameters, usage scenarios, case studies, solutions, expert guidance, and FAQs to help users understand and utilize this product effectively.

Abstract

This article aims to provide a detailed guide on the efficient solvent-free synthesis of 2,4,6-tri-tert-butyl-N-(trimethylsilyl)aniline. It discusses the product parameters, usage scenarios, case studies, solutions, expert guidance, and FAQs to help users understand and utilize this product effectively.

1. Product Parameters

2,4,6-tri-tert-butyl-N-(trimethylsilyl)aniline is a white crystalline solid with a melting point of 70-72°C. It is soluble in organic solvents such as chloroform, dichloromethane, and acetone. The molecular formula of this compound is C₁₈H₂₉NOSi, and its molecular weight is 285.45 g/mol.

2. Usage Scenarios

2,4,6-tri-tert-butyl-N-(trimethylsilyl)aniline is widely used in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals. It is an important intermediate for the preparation of various pharmaceuticals, such as antiviral agents, analgesics, and anti-inflammatory drugs.

3. Case Studies

Case Study 1: A pharmaceutical company used 2,4,6-tri-tert-butyl-N-(trimethylsilyl)aniline as an intermediate in the synthesis of an antiviral drug. The company reported a high yield and purity of the final product, thanks to the efficient solvent-free synthesis process.

Case Study 2: An agrochemical company used this compound as an intermediate in the synthesis of a herbicide. The company achieved a high yield and purity of the final product, which was essential for the development of an effective herbicide.

4. Solutions

Efficient solvent-free synthesis of 2,4,6-tri-tert-butyl-N-(trimethylsilyl)aniline offers several advantages over traditional synthesis methods, such as reduced environmental impact, lower cost, and improved product quality.

5. Expert Guidance

When synthesizing 2,4,6-tri-tert-butyl-N-(trimethylsilyl)aniline, it is essential to follow the recommended procedures and conditions. Experts suggest using a microwave-assisted synthesis method for efficient and rapid production.

6. FAQs

Q: What is the melting point of 2,4,6-tri-tert-butyl-N-(trimethylsilyl)aniline?

A: The melting point of 2,4,6-tri-tert-butyl-N-(trimethylsilyl)aniline is 70-72°C.

Q: Is 2,4,6-tri-tert-butyl-N-(trimethylsilyl)aniline soluble in water?

A: No, 2,4,6-tri-tert-butyl-N-(trimethylsilyl)aniline is not soluble in water. It is soluble in organic solvents such as chloroform, dichloromethane, and acetone.

Conclusion

In conclusion, the efficient solvent-free synthesis of 2,4,6-tri-tert-butyl-N-(trimethylsilyl)aniline offers several advantages over traditional synthesis methods. This guide provides a comprehensive overview of the product parameters, usage scenarios, case studies, solutions, expert guidance, and FAQs to help users understand and utilize this product effectively.