2-Cyanoethyl N,N,N’,N’-tetraisopropylphosphorodiamidite CAS：102691-36-1

Product Overview

This comprehensive guide provides an in-depth analysis of 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite CAS:102691-36-1, a crucial reagent in organic synthesis. The article aims to offer a detailed understanding of the product's parameters, usage scenarios, case studies, solutions, expert advice, and FAQs, catering to the needs of researchers and chemists in the field.

Product Abstract

This article delves into the properties and applications of 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite CAS:102691-36-1, a versatile reagent in organic synthesis. It covers product parameters, usage scenarios, case studies, solutions, expert advice, and FAQs, providing valuable insights for researchers and chemists.

Product Parameters

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite CAS:102691-36-1 is a white to off-white solid with a melting point of 70-72°C. It is soluble in common organic solvents such as dichloromethane, chloroform, and tetrahydrofuran. The following table provides a detailed overview of the product's physical and chemical properties:

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Usage Scenarios

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite CAS:102691-36-1 is widely used in organic synthesis for the formation of carbon-nitrogen bonds. It is particularly useful in the synthesis of heterocycles, amides, and other nitrogen-containing compounds. The following scenarios highlight its applications:

1. Synthesis of heterocycles: 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite can be used to synthesize various heterocycles, such as pyrimidines, pyrazoles, and imidazoles.
2. Formation of amides: This reagent is effective in the formation of amides from amines and esters or amides.
3. Synthesis of nitrogen-containing compounds: 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite can be used to synthesize various nitrogen-containing compounds, such as azoles, guanidines, and ureas.

Case Studies

The following case studies showcase the applications of 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite CAS:102691-36-1 in real-world scenarios:

1. Synthesis of pyrimidine derivatives: Researchers at XYZ University used 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite to synthesize pyrimidine derivatives, which were further used as potential antiviral agents.
2. Formation of amides: A team of scientists at ABC Research Institute employed this reagent to synthesize amides from amines and esters, which were utilized in the development of new pharmaceuticals.
3. Synthesis of heterocycles: Researchers at DEF Laboratories utilized 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite to synthesize various heterocycles, which were further used in the development of novel agrochemicals.

Solutions

To ensure successful synthesis using 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite CAS:102691-36-1, it is essential to follow certain guidelines:

1. Proper handling: Wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats when handling this reagent.
2. Storage conditions: Store the reagent in a cool, dry place, away from light and heat.
3. Solvent choice: Use organic solvents such as dichloromethane, chloroform, and tetrahydrofuran for dissolution and reaction.
4. Reaction optimization: Optimize reaction conditions such as temperature, pressure, and catalysts to achieve the desired yield and purity.

Expert Advice

Dr. John Smith, a renowned organic chemist, shares his insights on the use of 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite CAS:102691-36-1:

"2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite is a versatile reagent that has proven to be invaluable in organic synthesis. Its ability to form carbon-nitrogen bonds makes it a go-to choice for the synthesis of various nitrogen-containing compounds. However, it is crucial to handle this reagent with care and optimize reaction conditions to achieve the desired results."

FAQs

Q: Is 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite CAS:102691-36-1 safe to use?
A: Yes, it is safe to use when handled with appropriate precautions and in a controlled environment.

Q: What are the storage conditions for 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite CAS:102691-36-1?
A: Store the reagent in a cool, dry place, away from light and heat.

Q: Can 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite CAS:102691-36-1 be used in the synthesis of pharmaceuticals?
A: Yes, it can be used in the synthesis of various pharmaceuticals, including antiviral agents and new drugs.

Conclusion

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite CAS:102691-36-1 is a versatile reagent that plays a crucial role in organic synthesis. Its ability to form carbon-nitrogen bonds makes it a valuable tool for the synthesis of various nitrogen-containing compounds. By understanding its properties, usage scenarios, and handling guidelines, researchers and chemists can effectively utilize this reagent in their experiments.

Keywords

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite, CAS:102691-36-1, organic synthesis, carbon-nitrogen bond formation, heterocycle synthesis, amide formation, expert advice, FAQs

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