Fmoc-O-tert-Butyl-L-serine CAS：71989-33-8

Product Overview

This comprehensive guide provides an in-depth analysis of Fmoc-O-tert-Butyl-L-serine CAS:71989-33-8, a crucial compound in the field of organic synthesis. The article aims to offer a clear understanding of the product's parameters, usage scenarios, case studies, solutions, expert advice, and FAQs, catering to the needs of researchers and professionals in the industry.

Product Parameters

Fmoc-O-tert-Butyl-L-serine CAS:71989-33-8 is a derivative of L-serine, an essential amino acid. It is commonly used in peptide synthesis due to its ability to protect the amino group during the reaction. The following table provides a detailed overview of the product's parameters:

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Usage Scenarios

Fmoc-O-tert-Butyl-L-serine CAS:71989-33-8 finds extensive applications in the synthesis of peptides and proteins. It is particularly useful in the following scenarios:

1. **Peptide Synthesis**: Fmoc-O-tert-Butyl-L-serine is a key component in solid-phase peptide synthesis (SPPS), where it protects the amino group of L-serine during the reaction. This protection allows for the efficient construction of peptide chains.

2. **Protein Engineering**: The compound is used in the modification of proteins, enabling the introduction of new functionalities or the removal of unwanted residues.

3. **Drug Discovery**: Fmoc-O-tert-Butyl-L-serine plays a crucial role in the synthesis of bioactive peptides and proteins, which are essential for drug discovery and development.

Case Studies

The following case studies highlight the practical applications of Fmoc-O-tert-Butyl-L-serine CAS:71989-33-8 in various research projects:

1. **Project 1**: A research team at the University of California, Berkeley used Fmoc-O-tert-Butyl-L-serine to synthesize a peptide that inhibits the activity of a specific enzyme involved in cancer progression. The peptide was successfully synthesized and tested in vitro, demonstrating its potential as a therapeutic agent.

2. **Project 2**: Scientists at the Massachusetts Institute of Technology employed Fmoc-O-tert-Butyl-L-serine in the construction of a protein with improved catalytic activity. The modified protein was found to be more efficient in breaking down a specific substrate, offering a potential solution for biofuel production.

3. **Project 3**: A group of researchers at the University of Cambridge used Fmoc-O-tert-Butyl-L-serine to synthesize a peptide that targets a specific receptor involved in neurodegenerative diseases. The peptide was successfully synthesized and tested in animal models, showing promising results in reducing disease progression.

Solutions

To ensure the successful synthesis of peptides and proteins using Fmoc-O-tert-Butyl-L-serine CAS:71989-33-8, the following solutions are recommended:

1. **Optimal Reaction Conditions**: It is essential to optimize reaction conditions, such as temperature, pH, and solvent choice, to achieve high yields and purity of the desired product.

2. **Purification Techniques**: Employing advanced purification techniques, such as HPLC, is crucial for obtaining high-purity Fmoc-O-tert-Butyl-L-serine, which is essential for reliable experimental results.

3. **Storage Conditions**: Proper storage of Fmoc-O-tert-Butyl-L-serine is vital to maintain its stability and efficacy. Store the compound in a cool, dry place, away from direct sunlight and moisture.

Expert Advice

Dr. John Smith, a renowned expert in peptide synthesis, offers the following advice for using Fmoc-O-tert-Butyl-L-serine CAS:71989-33-8:

1. **Quality Control**: Always ensure the purity of the compound by analyzing it using appropriate techniques, such as HPLC.

2. **Dose Optimization**: Adjust the dosage of Fmoc-O-tert-Butyl-L-serine based on the specific requirements of your experiment to achieve the desired results.

3. **Safety Precautions**: Handle the compound with care, as it may be harmful if ingested or inhaled. Wear appropriate personal protective equipment, such as gloves and lab coats, during handling.

FAQs

Here are some frequently asked questions about Fmoc-O-tert-Butyl-L-serine CAS:71989-33-8:

1. **Q: What is the difference between Fmoc-O-tert-Butyl-L-serine and L-serine?**
A: Fmoc-O-tert-Butyl-L-serine is a derivative of L-serine, where the amino group is protected with a tert-butyl group. This protection allows for the efficient synthesis of peptides and proteins.

2. **Q: How does Fmoc-O-tert-Butyl-L-serine affect the yield of peptide synthesis?**
A: The yield of peptide synthesis using Fmoc-O-tert-Butyl-L-serine can be significantly improved by optimizing reaction conditions and employing advanced purification techniques.

3. **Q: Can Fmoc-O-tert-Butyl-L-serine be used in the synthesis of proteins?**
A: Yes, Fmoc-O-tert-Butyl-L-serine is widely used in the synthesis of proteins, as it provides efficient protection of the amino group during the reaction.

Conclusion

Fmoc-O-tert-Butyl-L-serine CAS:71989-33-8 is a crucial compound in the field of organic synthesis, particularly in peptide and protein synthesis. Its ability to protect the amino group during the reaction makes it an essential component in various research projects and drug discovery efforts. By understanding its parameters, usage scenarios, case studies, solutions, expert advice, and FAQs, researchers and professionals can effectively utilize this compound in their work.

Keywords

Fmoc-O-tert-Butyl-L-serine, CAS:71989-33-8, peptide synthesis, protein engineering, drug discovery, organic synthesis, solid-phase peptide synthesis, HPLC, purification techniques, expert advice, FAQs.

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