Solve Complex Reactions with N-(3-Bromo-5-fluoropyridin-2-yl)acetamide CAS 1065074-95-4

Product Overview

This comprehensive guide aims to provide an in-depth understanding of N-(3-Bromo-5-fluoropyridin-2-yl)acetamide CAS 1065074-95-4, a versatile reagent used in complex chemical reactions. The article will cover various aspects such as product parameters, usage scenarios, case studies, solutions, and expert guidance to help users make informed decisions.

Product Parameters

N-(3-Bromo-5-fluoropyridin-2-yl)acetamide CAS 1065074-95-4 is a white to off-white crystalline solid. It is soluble in common organic solvents such as dichloromethane, chloroform, and acetone. The melting point of this compound is around 130-132°C. The following table provides a detailed overview of its physical and chemical properties:

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Usage Scenarios

N-(3-Bromo-5-fluoropyridin-2-yl)acetamide CAS 1065074-95-4 is widely used in various chemical reactions, including:

1. Synthesis of heterocyclic compounds: This reagent can be used to synthesize pyridine derivatives, which are essential building blocks in pharmaceuticals and agrochemicals.
2. Cross-coupling reactions: It can be employed in Suzuki-Miyaura, Stille, and Negishi cross-coupling reactions to construct carbon-carbon bonds efficiently.
3. Cyclization reactions: The reagent can facilitate cyclization reactions, leading to the formation of various cyclic compounds.

Case Studies

1. Synthesis of pyridine derivatives: A research team successfully synthesized a series of pyridine derivatives using N-(3-Bromo-5-fluoropyridin-2-yl)acetamide CAS 1065074-95-4 as a key intermediate. The reaction conditions were optimized to achieve high yields and purity.
2. Suzuki-Miyaura cross-coupling reaction: In another study, the reagent was used in a Suzuki-Miyaura cross-coupling reaction to synthesize a biologically active compound. The reaction conditions were optimized to achieve high yields and regioselectivity.
3. Cyclization reaction: A research group employed N-(3-Bromo-5-fluoropyridin-2-yl)acetamide CAS 1065074-95-4 in a cyclization reaction to synthesize a cyclic compound with potential pharmaceutical applications.

Solutions

To ensure successful reactions using N-(3-Bromo-5-fluoropyridin-2-yl)acetamide CAS 1065074-95-4, consider the following solutions:

1. Optimize reaction conditions: Adjusting temperature, solvent, and catalyst concentrations can significantly impact the reaction yield and selectivity.
2. Purification techniques: Employing appropriate purification methods, such as recrystallization or column chromatography, can help obtain high-purity products.
3. Scale-up considerations: When scaling up the reaction, it is crucial to optimize the reaction vessel, stirring rate, and heating/cooling systems to maintain reaction efficiency.

Expert Guidance

Consulting with experienced chemists or chemical engineers can provide valuable insights into the use of N-(3-Bromo-5-fluoropyridin-2-yl)acetamide CAS 1065074-95-4. They can offer guidance on reaction optimization, purification techniques, and scale-up considerations.

Summary

N-(3-Bromo-5-fluoropyridin-2-yl)acetamide CAS 1065074-95-4 is a versatile reagent used in various complex chemical reactions. By understanding its product parameters, usage scenarios, case studies, solutions, and expert guidance, users can make informed decisions and achieve successful reactions.

Keywords

N-(3-Bromo-5-fluoropyridin-2-yl)acetamide, CAS 1065074-95-4, complex reactions, synthesis, cross-coupling, cyclization, heterocyclic compounds, pharmaceuticals, agrochemicals.

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