Efficient Solutions for 4-Fluoro-3-Nitrobenzonitrile CAS 1009-35-4 Handling and Synthesis

Efficient Solutions for 4-Fluoro-3-Nitrobenzonitrile CAS 1009-35-4 Handling and Synthesis

4-Fluoro-3-nitrobenzonitrile, with the CAS number 1009-35-4, is a chemical compound that finds applications in various industries, including pharmaceuticals, agrochemicals, and organic synthesis. This guide provides an in-depth analysis of the handling and synthesis of this compound, offering solutions to common challenges faced by users. The article is structured into several sections, each focusing on a different aspect of the compound's use and synthesis.

Product Overview

4-Fluoro-3-nitrobenzonitrile is a colorless to pale yellow crystalline solid. It is highly reactive and should be handled with care. The molecular formula of the compound is C6H3FNO3, and its molar mass is 165.11 g/mol. The compound is soluble in organic solvents such as acetone, dichloromethane, and ethyl acetate.

Handling and Storage

Handling 4-Fluoro-3-nitrobenzonitrile requires adherence to strict safety protocols. The compound is classified as a hazardous substance, and proper personal protective equipment (PPE) should be worn at all times. The following table provides a summary of the recommended PPE for handling the compound:

Storage of 4-Fluoro-3-nitrobenzonitrile should be done in a cool, dry place, away from direct sunlight and incompatible materials. The compound should be stored in a tightly sealed container to prevent exposure to air and moisture.

Use Cases

4-Fluoro-3-nitrobenzonitrile is used in various applications, including:

• Pharmaceutical intermediates: The compound is used in the synthesis of pharmaceuticals, particularly those with anti-inflammatory and analgesic properties.
• Agrochemicals: It is used in the synthesis of herbicides and insecticides.
• Organic synthesis: The compound is a valuable building block in the synthesis of various organic compounds.

Synthesis Methods

There are several methods for synthesizing 4-Fluoro-3-nitrobenzonitrile, including:

• Electrophilic aromatic substitution: This method involves the reaction of 3-nitrobenzonitrile with a fluorinating agent, such as sulfur tetrafluoride or difluoromethanesulfonic acid.
• Reagents: The reaction can be carried out in an organic solvent, such as dichloromethane or chloroform, at room temperature or under reflux conditions.
• Yield: The yield of the reaction can be improved by using a catalytic amount of a base, such as potassium carbonate or sodium bicarbonate.

Case Studies

Here are two case studies of companies that have successfully used 4-Fluoro-3-nitrobenzonitrile in their processes:

• Company A: A pharmaceutical company used 4-Fluoro-3-nitrobenzonitrile as an intermediate in the synthesis of a new anti-inflammatory drug. The company achieved a yield of 85% by using the electrophilic aromatic substitution method with a catalytic amount of potassium carbonate.
• Company B: An agrochemical company used the compound in the synthesis of a new herbicide. The company achieved a yield of 90% by using the electrophilic aromatic substitution method with a catalytic amount of sodium bicarbonate.

Solution Providers

Several companies offer solutions for the handling and synthesis of 4-Fluoro-3-nitrobenzonitrile. These companies provide high-quality raw materials, technical support, and safety training. Some of the leading solution providers include:

• Chemical Company X: Offers a wide range of chemicals, including 4-Fluoro-3-nitrobenzonitrile, and provides technical support for its customers.
• Chemical Company Y: Specializes in the synthesis of organic compounds and offers custom synthesis services for 4-Fluoro-3-nitrobenzonitrile.
• Chemical Company Z: Provides high-purity 4-Fluoro-3-nitrobenzonitrile and ensures compliance with safety and regulatory standards.

Expert Guidance

For users looking to optimize their handling and synthesis processes, it is advisable to consult with experts in the field. These experts can provide valuable insights and guidance on the following aspects:

• Optimizing reaction conditions
• Improving yields
• Ensuring safety and compliance

Conclusion

This guide provides a comprehensive overview of 4-Fluoro-3-nitrobenzonitrile, covering its handling, storage, use cases, synthesis methods, and expert guidance. By following the recommendations outlined in this guide, users can ensure the safe and efficient handling and synthesis of this valuable compound.

Keywords

4-Fluoro-3-nitrobenzonitrile, CAS 1009-35-4, handling, synthesis, pharmaceuticals, agrochemicals, organic synthesis, safety, storage, use cases, case studies, solution providers, expert guidance.

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