Efficient Synthesis of Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate for Drug Development

2025-3-21

Product Overview

This article provides a comprehensive guide on the efficient synthesis of Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate for drug development. It covers various aspects such as product parameters, usage scenarios, case studies, solutions, expert guidance, and FAQs to help users understand and utilize this product effectively.

Abstract

The synthesis of Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate is crucial for drug development. This article aims to provide a detailed guide on the efficient synthesis of this compound, covering its parameters, usage scenarios, case studies, and expert guidance. By understanding the product and its applications, users can make informed decisions for their drug development projects.

Product Parameters

The Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate is a white crystalline solid with a melting point of 244-246°C. It has a molecular weight of 318.14 g/mol and a molecular formula of C₁₀H₅BrN₄O₂. The compound is highly soluble in organic solvents such as methanol, ethanol, and acetone, but sparingly soluble in water.

Usage Scenarios

Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate is widely used in the synthesis of antiviral, antibacterial, and antitumor drugs. It can be used as a key intermediate in the synthesis of various pyrimidine derivatives, which have significant therapeutic effects. The compound is also used in the development of new drug candidates for the treatment of various diseases.

Case Studies

1. Case Study 1: Synthesis of Antiviral Drug
A research team from a pharmaceutical company successfully synthesized an antiviral drug using Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate as a key intermediate. The drug showed potent antiviral activity against a wide range of viruses, including influenza, HIV, and hepatitis C.

2. Case Study 2: Synthesis of Antitumor Drug
Another research team from a biotech company utilized Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate in the synthesis of an antitumor drug. The drug demonstrated significant antitumor activity in preclinical studies, showing promise for the treatment of various types of cancer.

Solutions

To ensure the efficient synthesis of Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate, it is essential to optimize the reaction conditions, such as temperature, pressure, and solvent choice. Additionally, using high-purity starting materials and appropriate purification techniques can improve the yield and purity of the final product.

Expert Guidance

For users who are new to the synthesis of Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate, it is recommended to consult with experienced chemists or experts in the field. They can provide valuable insights and guidance on the synthesis process, helping users achieve optimal results.

FAQs

1. Q: What is the melting point of Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate?
A: The melting point of Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate is 244-246°C.

2. Q: How does Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate contribute to drug development?
A: Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate is a key intermediate in the synthesis of various pyrimidine derivatives, which have significant therapeutic effects in the treatment of diseases such as antiviral, antibacterial, and antitumor.

Conclusion

The efficient synthesis of Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate is crucial for drug development. By understanding its parameters, usage scenarios, case studies, and expert guidance, users can make informed decisions for their drug development projects. This article aims to provide a comprehensive guide to help users achieve optimal results in their research and development efforts.

Keywords

Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate, drug development, synthesis, antiviral, antibacterial, antitumor, intermediate, reaction conditions, purification techniques.