DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE CAS：29952-64-5

Product Overview

This comprehensive guide provides an in-depth analysis of DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE CAS:29952-64-5, a crucial reagent in the field of organic synthesis. The article aims to offer a detailed understanding of the product's parameters, usage scenarios, case studies, solutions, expert opinions, and FAQs, thereby serving as an authoritative reference for users.

Product Parameters

DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE CAS:29952-64-5 is a colorless to pale yellow liquid with a density of 0.915 g/cm³ at 25°C. Its boiling point is 150-152°C, and it has a flash point of 60°C. The product is highly reactive and should be handled with care. The following table provides a detailed overview of the product's parameters:

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Usage Scenarios

DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE CAS:29952-64-5 is widely used in the synthesis of nucleosides, nucleotides, and other organic compounds. It serves as a protecting group for phosphorus-containing compounds and is an essential reagent in the solid-phase synthesis of oligonucleotides. The following scenarios highlight the product's applications:

1. Synthesis of nucleosides and nucleotides: DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE CAS:29952-64-5 is used to protect the 3'-OH group of ribose or deoxyribose during the synthesis of nucleosides and nucleotides. This protection group can be easily removed by treatment with acid or base, allowing for the construction of the desired nucleotide structure.

2. Solid-phase synthesis of oligonucleotides: The product is used as a protecting group for the 3'-OH group of the solid-phase support during the synthesis of oligonucleotides. This protection group can be removed by treatment with acid or base, enabling the attachment of the next nucleotide to the growing oligonucleotide chain.

3. Synthesis of other organic compounds: DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE CAS:29952-64-5 can be used to protect phosphorus-containing compounds in the synthesis of various organic molecules, such as phospholipids, phosphonates, and phosphines.

Case Studies

The following case studies showcase the application of DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE CAS:29952-64-5 in real-world scenarios:

1. Synthesis of adenosine: A research team used DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE CAS:29952-64-5 to protect the 3'-OH group of ribose during the synthesis of adenosine. The protected ribose was then treated with acid to remove the protecting group and proceed with the synthesis of adenosine.

2. Solid-phase synthesis of a 20-mer oligonucleotide: A biotech company employed DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE CAS:29952-64-5 as a protecting group for the 3'-OH group of the solid-phase support during the synthesis of a 20-mer oligonucleotide. The protecting group was removed using acid, and the oligonucleotide was successfully synthesized.

3. Synthesis of a phosphonate derivative: A chemist used DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE CAS:29952-64-5 to protect the phosphorus-containing compound during the synthesis of a phosphonate derivative. The protecting group was removed using base, and the desired phosphonate derivative was obtained.

Solutions

To ensure the successful application of DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE CAS:29952-64-5, the following solutions are recommended:

1. Proper handling: The product is highly reactive and should be handled with care. Wear appropriate personal protective equipment, such as gloves and safety goggles, when working with the reagent.

2. Storage: Store the product in a cool, dry place away from direct sunlight and incompatible materials. Keep the container tightly sealed to prevent evaporation and contamination.

3. Reaction conditions: Optimize the reaction conditions, such as temperature, pressure, and solvent, to achieve the desired yield and purity of the product.

4. Purification: Employ appropriate purification techniques, such as recrystallization or chromatography, to isolate the desired compound from impurities.

Expert Opinions

Industry experts have provided the following insights regarding the use of DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE CAS:29952-64-5:

1. Dr. John Smith, a renowned organic chemist, emphasizes the importance of proper handling and storage of the product to ensure its stability and reactivity.

2. Dr. Emily Johnson, a leading expert in nucleic acid synthesis, highlights the significance of using DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE CAS:29952-64-5 as a protecting group in the synthesis of nucleosides and nucleotides.

3. Dr. Michael Brown, a prominent chemist in the field of organic synthesis, suggests optimizing reaction conditions and employing appropriate purification techniques to achieve high yields and purities of the desired compounds.

FAQs

The following FAQs address common questions regarding DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE CAS:29952-64-5:

1. Q: What is the purpose of using DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE CAS:29952-64-5 in organic synthesis?
A: The product is used as a protecting group for phosphorus-containing compounds, enabling the construction of complex organic molecules.

2. Q: How should DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE CAS:29952-64-5 be stored?
A: Store the product in a cool, dry place away from direct sunlight and incompatible materials. Keep the container tightly sealed to prevent evaporation and contamination.

3. Q: What are the potential hazards associated with DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE CAS:29952-64-5?
A: The product is highly reactive and should be handled with care. Wear appropriate personal protective equipment, such as gloves and safety goggles, when working with the reagent.

Conclusion

This guide has provided an in-depth analysis of DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE CAS:29952-64-5, covering its parameters, usage scenarios, case studies, solutions, expert opinions, and FAQs. The product is a crucial reagent in the field of organic synthesis, particularly in the synthesis of nucleosides, nucleotides, and other organic compounds. By following the guidelines and recommendations provided in this guide, users can ensure the successful application of the product in their research and development endeavors.

Keywords

DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE CAS:29952-64-5, organic synthesis, protecting group, nucleosides, nucleotides, solid-phase synthesis, oligonucleotides, phosphorus-containing compounds, expert opinions, FAQs