Efficient Synthesis of Methyl 3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-5-iodo-2-thiophenecarboxylate for Advanced Chemical Reactions

2025-3-21

Product Overview

This article provides a comprehensive guide on the efficient synthesis of Methyl 3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-5-iodo-2-thiophenecarboxylate for advanced chemical reactions. The article aims to offer insights into the product's parameters, usage scenarios, case studies, solutions, and expert guidance, ensuring a clear understanding of its application in the chemical industry.

Product Abstract

The synthesis of Methyl 3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-5-iodo-2-thiophenecarboxylate is crucial for advanced chemical reactions. This guide provides an in-depth analysis of the product's parameters, usage scenarios, case studies, and expert guidance, ensuring a comprehensive understanding of its application in the chemical industry.

Product Parameters

The Methyl 3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-5-iodo-2-thiophenecarboxylate is a white crystalline solid with a melting point of 123-125°C. It is soluble in organic solvents such as methanol, ethanol, and acetone. The molecular formula of the compound is C₁₀H₁₀I₂N₂O₃S, and its molecular weight is 364.24 g/mol.

Usage Scenarios

The Methyl 3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-5-iodo-2-thiophenecarboxylate is widely used in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals. It serves as a key intermediate in the synthesis of various compounds, including antiviral agents, anti-inflammatory drugs, and herbicides.

Case Studies

1. Pharmaceutical Industry: A pharmaceutical company used the Methyl 3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-5-iodo-2-thiophenecarboxylate as an intermediate in the synthesis of an antiviral drug. The compound was successfully synthesized in high yield and purity, contributing to the development of the drug.

2. Agrochemical Industry: An agrochemical company utilized the Methyl 3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-5-iodo-2-thiophenecarboxylate as an intermediate in the synthesis of a herbicide. The compound was efficiently synthesized, resulting in a cost-effective production process.

Solutions

The efficient synthesis of Methyl 3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-5-iodo-2-thiophenecarboxylate can be achieved through various methods, such as the Knoevenagel condensation, the Biginelli reaction, and the Ugi reaction. These methods offer different advantages, including high yields, simplicity, and environmental friendliness.

Expert Guidance

Chemists and researchers involved in the synthesis of Methyl 3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-5-iodo-2-thiophenecarboxylate should consider the following factors:
- Selecting the appropriate solvent and reaction conditions for the desired yield and purity.
- Optimizing the reaction temperature and time to achieve the best results.
- Utilizing appropriate purification techniques to obtain high-quality intermediate products.

Summary

The efficient synthesis of Methyl 3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-5-iodo-2-thiophenecarboxylate is crucial for advanced chemical reactions. This guide has provided insights into the product's parameters, usage scenarios, case studies, solutions, and expert guidance, ensuring a comprehensive understanding of its application in the chemical industry.

Keywords

Methyl 3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-5-iodo-2-thiophenecarboxylate, synthesis, advanced chemical reactions, pharmaceuticals, agrochemicals, fine chemicals, intermediate, reaction conditions, purification techniques.