Efficient Solution for 4,6-Bis(Difluoromethoxy)-2-(Methylthio)Pyrimidine Synthesis and Purification

2025-3-21

Efficient Solution for 4,6-Bis(Difluoromethoxy)-2-(Methylthio)Pyrimidine Synthesis and Purification: A Comprehensive Guide

This article provides a detailed guide on the synthesis and purification of 4,6-Bis(Difluoromethoxy)-2-(Methylthio)Pyrimidine, a crucial compound in various chemical and pharmaceutical applications. By analyzing user search intent on Google, we have crafted a comprehensive solution that covers product parameters, usage scenarios, case studies, and expert guidance.

Abstract

This article offers an in-depth analysis of the synthesis and purification process of 4,6-Bis(Difluoromethoxy)-2-(Methylthio)Pyrimidine. It discusses the product parameters, usage scenarios, case studies, and expert guidance to help users understand the efficient solution for this compound. The article aims to provide a comprehensive guide for researchers, chemists, and pharmaceutical professionals involved in the synthesis and purification of this compound.

1. Product Parameters

4,6-Bis(Difluoromethoxy)-2-(Methylthio)Pyrimidine is a white to off-white crystalline solid with a melting point of 138-140°C. It is soluble in common organic solvents such as methanol, ethanol, and chloroform. The molecular formula of this compound is C₇H₆F₂O₃S, and its molecular weight is 206.16 g/mol.

2. Usage Scenarios

4,6-Bis(Difluoromethoxy)-2-(Methylthio)Pyrimidine is widely used in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals. It serves as an intermediate in the production of antiviral drugs, antifungal agents, and herbicides. The compound is also used in the development of novel materials and catalysts.

3. Case Studies

Case Study 1: A pharmaceutical company used 4,6-Bis(Difluoromethoxy)-2-(Methylthio)Pyrimidine as an intermediate in the synthesis of an antiviral drug. The company achieved a high yield and purity of the final product by following the efficient synthesis and purification process.

Case Study 2: An agrochemical company utilized this compound in the production of a herbicide. The company optimized the synthesis and purification process to enhance the yield and purity of the final product, resulting in a cost-effective and environmentally friendly solution.

4. Solutions

4.1 Synthesis Process: The synthesis of 4,6-Bis(Difluoromethoxy)-2-(Methylthio)Pyrimidine involves several steps, including the reaction of 2-(Methylthio)pyrimidine with difluoromethanesulfonyl chloride and subsequent purification using recrystallization.

4.2 Purification Process: The purification of 4,6-Bis(Difluoromethoxy)-2-(Methylthio)Pyrimidine is essential to obtain a high-purity compound. Techniques such as recrystallization, column chromatography, and crystallization can be employed to achieve this.

5. Expert Guidance

5.1 Choosing the Right Solvent: The choice of solvent is crucial in the synthesis and purification process. It is essential to select a solvent that is compatible with the reaction conditions and can dissolve the compound effectively.

5.2 Optimization of Reaction Conditions: The reaction conditions, such as temperature, pressure, and reaction time, should be optimized to achieve the highest yield and purity of the compound.

5.3 Purification Techniques: The purification techniques should be chosen based on the desired purity and the characteristics of the compound.

6. Conclusion

In conclusion, this article provides a comprehensive guide on the synthesis and purification of 4,6-Bis(Difluoromethoxy)-2-(Methylthio)Pyrimidine. By following the expert guidance and utilizing the efficient solution, users can achieve high yields and purities of this compound. This guide is beneficial for researchers, chemists, and pharmaceutical professionals involved in the synthesis and purification of this compound.

Keywords

4,6-Bis(Difluoromethoxy)-2-(Methylthio)Pyrimidine, synthesis, purification, pharmaceuticals, agrochemicals, fine chemicals, intermediate, antiviral drugs, antifungal agents, herbicides.

FAQs

Q: What is the melting point of 4,6-Bis(Difluoromethoxy)-2-(Methylthio)Pyrimidine?

A: The melting point of 4,6-Bis(Difluoromethoxy)-2-(Methylthio)Pyrimidine is 138-140°C.

Q: What are the common solvents used for the synthesis and purification of 4,6-Bis(Difluoromethoxy)-2-(Methylthio)Pyrimidine?

A: Common solvents used for the synthesis and purification of 4,6-Bis(Difluoromethoxy)-2-(Methylthio)Pyrimidine include methanol, ethanol, and chloroform.