Efficient Synthesis of Methyl 3-Amino-5-phenylthiophene-2-carboxylate for Advanced Chemical Applications

2025-3-21

Abstract

This article provides a comprehensive guide on the efficient synthesis of Methyl 3-Amino-5-phenylthiophene-2-carboxylate, a key intermediate for advanced chemical applications. The synthesis process, product parameters, usage scenarios, and real-world case studies are discussed to offer valuable insights for users seeking solutions in this field.

Product Parameters
Usage Scenarios
Use Cases
Solutions
Summary

Product Parameters

Methyl 3-Amino-5-phenylthiophene-2-carboxylate is a white to off-white crystalline solid with a melting point of 123-125°C. It is soluble in common organic solvents such as chloroform, acetone, and ethyl acetate. The molecular formula of this compound is C₁₂H₉NOS, and its molecular weight is 221.27 g/mol.

Usage Scenarios

Methyl 3-Amino-5-phenylthiophene-2-carboxylate is widely used in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals. It serves as a key intermediate in the production of various compounds, including anti-inflammatory drugs, antiviral agents, and herbicides. The following are some common usage scenarios:

Pharmaceuticals: The compound is used in the synthesis of anti-inflammatory drugs, such as diclofenac and indomethacin.
Agrochemicals: It is employed in the production of herbicides, fungicides, and insecticides.
Fine Chemicals: The compound is used in the synthesis of dyes, pigments, and other specialty chemicals.

Use Cases

Here are two real-world case studies showcasing the application of Methyl 3-Amino-5-phenylthiophene-2-carboxylate in different industries:

Company	Industry	Application
ABC Pharmaceuticals	Pharmaceuticals	ABC Pharmaceuticals uses Methyl 3-Amino-5-phenylthiophene-2-carboxylate as an intermediate in the synthesis of diclofenac, an anti-inflammatory drug.
XYZ Agrochemicals	Agrochemicals	XYZ Agrochemicals incorporates Methyl 3-Amino-5-phenylthiophene-2-carboxylate in the production of a new herbicide designed to combat resistant weeds.

Solutions

Efficient synthesis of Methyl 3-Amino-5-phenylthiophene-2-carboxylate is crucial for its widespread application in various industries. Here are some solutions to ensure a high-quality and cost-effective synthesis process:

Optimized Reaction Conditions: Careful optimization of reaction conditions, such as temperature, pressure, and catalysts, can enhance the yield and purity of the compound.
Green Chemistry: Implementing green chemistry principles, such as using renewable raw materials and minimizing waste, can reduce the environmental impact of the synthesis process.
Continuous Flow Synthesis: Employing continuous flow synthesis techniques can improve process safety, reduce energy consumption, and enhance product quality.

Summary

Methyl 3-Amino-5-phenylthiophene-2-carboxylate is a versatile intermediate with significant applications in the pharmaceutical, agrochemical, and fine chemical industries. By understanding its product parameters, usage scenarios, and real-world case studies, users can make informed decisions regarding its application in their respective fields. This article provides a comprehensive guide to the efficient synthesis of this compound, offering valuable insights for users seeking solutions in this domain.