Efficient 2-Thiazolesulfonyl Chloride CAS 100481-09-2 for Synthesis Challenges

2025-3-21

Efficient 2-Thiazolesulfonyl Chloride CAS 100481-09-2 for Synthesis Challenges

Efficient 2-Thiazolesulfonyl Chloride CAS 100481-09-2 is a versatile reagent widely used in the synthesis of various organic compounds. This guide aims to provide a comprehensive overview of the product, including its parameters, usage scenarios, case studies, solutions, and expert guidance. By the end of this article, readers will have a clear understanding of how this compound can be effectively utilized in synthesis challenges.

Product Overview

2-Thiazolesulfonyl Chloride, also known as 2-thiazole-4-sulfonyl chloride, is a white to off-white crystalline solid. It is highly reactive and is commonly used as a sulfonating agent in organic synthesis. The CAS number of this compound is 100481-09-2.

Product Parameters

Parameter	Value
Molecular Formula	C₄H₂N₂SO₃Cl
Molecular Weight	191.6 g/mol
Appearance	White to off-white crystalline solid
Purity	≥98%
Boiling Point	≥300°C

Usage Scenarios

2-Thiazolesulfonyl Chloride is a versatile reagent that can be used in various synthesis challenges. Some common usage scenarios include:

Preparation of sulfonated heterocycles
Synthesis of sulfonamide derivatives
Construction of thiazole-containing compounds

Case Studies

Here are two case studies demonstrating the use of 2-Thiazolesulfonyl Chloride in synthesis challenges:

Case Study 1: Synthesis of Sulfonated Heterocycles

One of the primary applications of 2-Thiazolesulfonyl Chloride is in the synthesis of sulfonated heterocycles. For instance, it can be used to synthesize 2-thiazole-4-sulfonic acid esters, which are important intermediates in the pharmaceutical industry.

Case Study 2: Synthesis of Sulfonamide Derivatives

2-Thiazolesulfonyl Chloride can also be used to synthesize sulfonamide derivatives, which are widely used as antibiotics and antifungal agents. One example is the synthesis of N-(2-thiazol-4-yl)sulfonamide, which has been reported to exhibit potent antifungal activity.

Solutions

When using 2-Thiazolesulfonyl Chloride in synthesis challenges, it is important to consider the following solutions:

Proper handling and storage to prevent decomposition
Optimization of reaction conditions to achieve high yields
Use of appropriate solvents and reagents to minimize side reactions

Expert Guidance

For users who are new to the synthesis of organic compounds using 2-Thiazolesulfonyl Chloride, it is advisable to consult with experts in the field. They can provide valuable insights and guidance on the following aspects:

Reaction mechanisms and pathways
Optimization of reaction conditions
Handling and storage of hazardous reagents

Conclusion

In conclusion, Efficient 2-Thiazolesulfonyl Chloride CAS 100481-09-2 is a valuable reagent for various synthesis challenges. Its versatility, coupled with its high purity and reactivity, makes it an ideal choice for the preparation of sulfonated heterocycles, sulfonamide derivatives, and other thiazole-containing compounds. By following the guidelines provided in this article, users can effectively utilize this compound in their synthesis endeavors.