Efficient Synthesis of Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate for Drug Development

2025-3-21

Product Overview

This article provides a comprehensive guide on the efficient synthesis of Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate for drug development. It covers various aspects such as product parameters, usage scenarios, case studies, solutions, expert guidance, and FAQs to help users understand and utilize this product effectively.

Abstract

The synthesis of Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate is crucial for drug development. This article aims to provide a detailed guide on the efficient synthesis of this compound, covering its parameters, usage scenarios, case studies, and expert guidance. By understanding the product and its applications, users can make informed decisions for their drug development projects.

Product Parameters

The Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate is a white crystalline solid with a melting point of 244-246°C. It has a molecular weight of 335.12 g/mol and a molecular formula of C₉H₅BrN₄O₂. The compound is highly soluble in organic solvents such as methanol, ethanol, and acetone, but sparingly soluble in water.

Usage Scenarios

Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate is widely used in the synthesis of antiviral, antibacterial, and antitumor drugs. It can be used as a key intermediate in the synthesis of various pyrimidine derivatives, which have significant therapeutic effects. The compound is also used in the development of new drugs for the treatment of neurological disorders, cardiovascular diseases, and other diseases.

Case Studies

1. Case Study 1: Synthesis of Antiviral Drug
A research team from a pharmaceutical company successfully synthesized an antiviral drug using Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate as a key intermediate. The drug showed potent antiviral activity against various viruses, including influenza A and B, and was further developed for clinical trials.

2. Case Study 2: Synthesis of Antitumor Drug
Another research team from a biotech company utilized Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate in the synthesis of an antitumor drug. The drug demonstrated significant antitumor activity in vitro and in vivo, and is currently undergoing preclinical studies.

Solutions

To ensure the efficient synthesis of Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate, the following solutions can be adopted:

1. Optimize reaction conditions: Adjusting the reaction temperature, pressure, and solvent can improve the yield and purity of the compound.
2. Use high-quality raw materials: High-quality raw materials can ensure the stability and reproducibility of the synthesis process.
3. Employ advanced synthetic techniques: Utilize modern synthetic techniques, such as microwave-assisted synthesis and continuous flow synthesis, to enhance the efficiency and scalability of the process.

Expert Guidance

For users who are new to the synthesis of Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate, it is recommended to consult with experienced experts in the field. They can provide valuable insights and guidance on the synthesis process, helping users avoid common pitfalls and achieve optimal results.

FAQs

1. Q: What is the melting point of Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate?
A: The melting point of Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate is 244-246°C.

2. Q: Is Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate soluble in water?
A: Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate is sparingly soluble in water.

3. Q: What are the main applications of Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate?
A: Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate is widely used in the synthesis of antiviral, antibacterial, and antitumor drugs, as well as in the development of new drugs for the treatment of neurological disorders, cardiovascular diseases, and other diseases.

Conclusion

In conclusion, the efficient synthesis of Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate is crucial for drug development. This article has provided a comprehensive guide on the product parameters, usage scenarios, case studies, solutions, expert guidance, and FAQs. By understanding and utilizing this product effectively, users can contribute to the advancement of drug development and improve patient care.

Keywords

Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate, drug development, synthesis, antiviral, antibacterial, antitumor, intermediate, pharmaceutical, biotech