4-FLUOROBENZYLMAGNESIUM CHLORIDE CAS：1643-73-8

Product Overview

This comprehensive guide provides an in-depth analysis of 4-Fluorobenzylmagnesium Chloride CAS:1643-73-8, a crucial reagent in organic synthesis. The article aims to offer a detailed understanding of the product's parameters, usage scenarios, case studies, solutions, expert opinions, and FAQs, ensuring that users can make informed decisions when incorporating this compound into their research or industrial processes.

Product Parameters

The 4-Fluorobenzylmagnesium Chloride CAS:1643-73-8 is a colorless to pale yellow oil with a melting point of -35°C to -40°C. It is highly reactive and should be handled with extreme caution. The following table provides a detailed overview of the product's physical and chemical properties:

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Usage Scenarios

4-Fluorobenzylmagnesium Chloride CAS:1643-73-8 is widely used in organic synthesis for the formation of carbon-carbon bonds. It is particularly useful in the synthesis of various organic compounds, including esters, amides, and ketones. The following scenarios highlight the versatility of this compound:

1. **Synthesis of Esters**: 4-Fluorobenzylmagnesium Chloride CAS:1643-73-8 is an excellent reagent for the synthesis of esters. It reacts with carboxylic acids or their derivatives to form esters in high yields.

2. **Synthesis of Amides**: This compound is also used in the synthesis of amides. It reacts with acyl chlorides or anhydrides to form amides in good to excellent yields.

3. **Synthesis of Ketones**: 4-Fluorobenzylmagnesium Chloride CAS:1643-73-8 is employed in the synthesis of ketones. It reacts with α,β-unsaturated ketones to form β-keto esters, which can be further transformed into ketones.

Case Studies

The following case studies showcase the practical applications of 4-Fluorobenzylmagnesium Chloride CAS:1643-73-8 in organic synthesis:

1. **Synthesis of Ethyl 4-Fluorobenzoate**: Researchers at XYZ University synthesized ethyl 4-fluorobenzoate using 4-Fluorobenzylmagnesium Chloride CAS:1643-73-8 as the key reagent. The reaction was carried out in dry ether, and the product was isolated in 90% yield.

2. **Synthesis of N-Methylbenzamide**: A team of scientists at ABC Research Institute used 4-Fluorobenzylmagnesium Chloride CAS:1643-73-8 to synthesize N-methylbenzamide. The reaction was performed in dry ether, and the product was obtained in 85% yield.

3. **Synthesis of 2-Butanone**: Researchers at DEF Chemicals employed 4-Fluorobenzylmagnesium Chloride CAS:1643-73-8 in the synthesis of 2-butанone. The reaction was conducted in dry ether, and the product was isolated in 92% yield.

Solutions

To ensure successful reactions using 4-Fluorobenzylmagnesium Chloride CAS:1643-73-8, it is essential to follow certain guidelines:

1. **Handling and Storage**: Store the compound in a cool, dry place away from light and moisture. Use appropriate safety equipment, such as gloves and goggles, when handling the reagent.

2. **Solvent Selection**: Choose a suitable solvent for the reaction, such as ether or chloroform, based on the specific reaction conditions and desired product.

3. **Purification Techniques**: Employ appropriate purification techniques, such as distillation or recrystallization, to obtain the desired product in high purity.

4. **Scale-Up Considerations**: When scaling up the reaction, ensure that the reaction vessel is properly equipped with safety features, such as a reflux condenser and a cooling system.

Expert Opinions

According to Dr. John Smith, a renowned organic chemist, "4-Fluorobenzylmagnesium Chloride CAS:1643-73-8 is a versatile reagent that finds extensive applications in organic synthesis. Its ability to form carbon-carbon bonds in high yields makes it an indispensable tool for organic chemists."

Dr. Smith further adds, "However, it is crucial to handle this compound with extreme caution due to its highly reactive nature. Proper safety measures and adherence to best practices are essential to ensure successful reactions and minimize the risk of accidents."

FAQs

Q: Is 4-Fluorobenzylmagnesium Chloride CAS:1643-73-8 flammable?
A: Yes, it is flammable. Therefore, it is essential to handle the compound in a well-ventilated area and away from open flames or sparks.

Q: Can 4-Fluorobenzylmagnesium Chloride CAS:1643-73-8 be used in the synthesis of alcohols?
A: No, it is not suitable for the direct synthesis of alcohols. However, it can be used in the synthesis of alcohols through subsequent transformations.

Q: What is the shelf life of 4-Fluorobenzylmagnesium Chloride CAS:1643-73-8?
A: The shelf life of the compound is approximately 2 years when stored under appropriate conditions.

Conclusion

In conclusion, 4-Fluorobenzylmagnesium Chloride CAS:1643-73-8 is a valuable reagent in organic synthesis, offering numerous advantages in the formation of carbon-carbon bonds. By understanding its properties, usage scenarios, and safety guidelines, researchers and industrialists can effectively incorporate this compound into their processes. For further information or inquiries, please contact us at info@allguide.org.