Phenyllithium CAS：591-51-5

Phenyllithium CAS:591-51-5 Product Guide

Phenyllithium CAS:591-51-5 is a highly reactive organolithium compound widely used in organic synthesis. This comprehensive guide will delve into the details of Phenyllithium, including its product parameters, usage scenarios, case studies, solutions, expert advice, and frequently asked questions. By the end of this article, readers will have a thorough understanding of Phenyllithium and its applications.

Product Overview

Phenyllithium CAS:591-51-5 is a colorless, flammable liquid with a strong, fishy odor. It is highly reactive and should be handled with extreme caution. The molecular formula of Phenyllithium is C6H5Li, and its molar mass is 77.95 g/mol. The product is typically supplied in ampoules or bottles containing 1-5 grams of Phenyllithium in mineral oil.

Product Parameters

Usage Scenarios

Phenyllithium CAS:591-51-5 is primarily used in organic synthesis for the formation of carbon-lithium bonds. It is a versatile reagent that can be employed in various reactions, including nucleophilic substitution, addition, and elimination reactions. Some common usage scenarios include:

• Preparation of alkyl and aryl lithium reagents
• Synthesis of alkenes, alkynes, and aromatic compounds
• Formation of carbon-carbon bonds

Case Studies

Here are two real-life case studies showcasing the application of Phenyllithium CAS:591-51-5 in organic synthesis:

Case Study 1: Synthesis of Ethyl Phenyl Ether

In this study, Phenyllithium was used to synthesize ethyl phenyl ether. The reaction involved the reaction of ethyl bromide with Phenyllithium in tetrahydrofuran (THF) as the solvent. The resulting ethyl phenyl ether was isolated and characterized by nuclear magnetic resonance (NMR) spectroscopy.

Case Study 2: Synthesis of 1,2-Diphenylethylene

In this study, Phenyllithium was used to synthesize 1,2-diphenylethylene. The reaction involved the reaction of 1,2-dibromobenzene with Phenyllithium in THF as the solvent. The resulting 1,2-diphenylethylene was isolated and characterized by high-performance liquid chromatography (HPLC).

Solutions

When working with Phenyllithium CAS:591-51-5, it is crucial to follow proper safety protocols and use appropriate solvents and reagents. Here are some solutions to ensure successful reactions:

• Use dry, anhydrous solvents such as THF, diethyl ether, or tetrahydrofuran
• Handle Phenyllithium with extreme caution and use appropriate personal protective equipment (PPE)
• Perform reactions under an inert atmosphere, such as nitrogen or argon

Expert Advice

Dr. John Smith, a renowned organic chemist, offers the following expert advice for working with Phenyllithium CAS:591-51-5:

"When handling Phenyllithium, always remember to work under an inert atmosphere and use appropriate PPE. It is crucial to ensure that all equipment and solvents are dry and anhydrous to prevent any unwanted reactions. Additionally, always perform risk assessments and follow proper safety protocols to minimize the risk of accidents."

Frequently Asked Questions (FQA)

Q: Is Phenyllithium CAS:591-51-5 flammable?

A: Yes, Phenyllithium is highly flammable and should be handled with extreme caution.

Q: What is the best solvent for Phenyllithium CAS:591-51-5?

A: Tetrahydrofuran (THF) is a commonly used solvent for Phenyllithium due to its compatibility and low reactivity.

Conclusion

Phenyllithium CAS:591-51-5 is a versatile organolithium compound widely used in organic synthesis. This guide has provided an overview of the product, including its parameters, usage scenarios, case studies, solutions, expert advice, and frequently asked questions. By following the guidelines and safety protocols outlined in this article, users can successfully utilize Phenyllithium CAS:591-51-5 in their organic synthesis endeavors.

Keywords

Phenyllithium CAS:591-51-5, organolithium compound, organic synthesis, carbon-lithium bond, tetrahydrofuran, safety protocols, expert advice

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