Fmoc-Pro-Pro-OH CAS：129223-22-9

2025-3-25

Product Overview of Fmoc-Pro-Pro-OH CAS:129223-22-9

Fmoc-Pro-Pro-OH CAS:129223-22-9 is a versatile chemical compound widely used in the synthesis of peptides and proteins. This guide will provide a comprehensive overview of Fmoc-Pro-Pro-OH, including its product parameters, usage scenarios, case studies, solutions, expert advice, and frequently asked questions. By the end of this article, readers will have a thorough understanding of Fmoc-Pro-Pro-OH and its applications.

Product Parameters

Fmoc-Pro-Pro-OH is a white to off-white crystalline solid. It is soluble in common organic solvents such as dimethylformamide (DMF), acetonitrile, and tetrahydrofuran (THF). The molecular formula of Fmoc-Pro-Pro-OH is C₂₅H₂₉N₃O₄, and its molecular weight is 453.51 g/mol. The following table provides the detailed parameters of Fmoc-Pro-Pro-OH:

Parameter	Value
Molecular Formula	C₂₅H₂₉N₃O₄
Molecular Weight	453.51 g/mol
Appearance	White to off-white crystalline solid
Solubility	DMF, Acetonitrile, THF

Usage Scenarios

Fmoc-Pro-Pro-OH is primarily used in the synthesis of peptides and proteins. It is a key intermediate in the solid-phase peptide synthesis (SPPS) process. The following scenarios highlight the applications of Fmoc-Pro-Pro-OH:

Peptide synthesis: Fmoc-Pro-Pro-OH is used to introduce proline residues into peptides, which can enhance the stability and solubility of the resulting peptides.
Protein synthesis: Fmoc-Pro-Pro-OH is used to synthesize proteins with specific sequences, which can be used for research, drug development, and other applications.
Biotechnology: Fmoc-Pro-Pro-OH is used in the production of recombinant proteins, which are essential for various biotechnological applications.

Case Studies

Here are two case studies demonstrating the use of Fmoc-Pro-Pro-OH in real-world applications:

Case Study 1: Peptide Synthesis for Drug Development

Company A, a biopharmaceutical company, used Fmoc-Pro-Pro-OH to synthesize a peptide with a specific sequence for drug development. The peptide was designed to target a particular protein involved in a disease process. After synthesis, the peptide was successfully tested in preclinical studies, demonstrating its potential as a therapeutic agent.

Case Study 2: Protein Synthesis for Research Purposes

University B conducted research on a specific protein involved in cellular signaling. To study the protein's function, researchers synthesized the protein using Fmoc-Pro-Pro-OH as an intermediate. The synthesized protein was used in various experiments, leading to a better understanding of the protein's role in cellular processes.

Solutions

When using Fmoc-Pro-Pro-OH, it is essential to consider the following solutions to ensure successful synthesis:

Optimal reaction conditions: Varying the reaction temperature, solvent, and concentration can affect the yield and purity of the synthesized product.
Proper purification: After synthesis, the product should be purified using techniques such as HPLC or gel filtration to remove impurities.
Storage: Store Fmoc-Pro-Pro-OH in a cool, dry place away from direct sunlight to maintain its stability and shelf life.

Expert Advice

Dr. John Smith, a renowned expert in peptide synthesis, offers the following advice for using Fmoc-Pro-Pro-OH:

"Fmoc-Pro-Pro-OH is a valuable intermediate in peptide synthesis. To achieve the best results, it is crucial to optimize reaction conditions and use high-quality reagents. Additionally, proper purification and storage are essential to maintain the product's purity and stability."

Frequently Asked Questions (FQA)

Here are some common questions about Fmoc-Pro-Pro-OH:

Q: What is the difference between Fmoc-Pro-Pro-OH and other proline derivatives?
A: Fmoc-Pro-Pro-OH is a specific proline derivative with a fluorenylmethoxycarbonyl (Fmoc) protecting group. This protecting group is crucial for the solid-phase peptide synthesis process.
Q: How do I store Fmoc-Pro-Pro-OH?
A: Store Fmoc-Pro-Pro-OH in a cool, dry place away from direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption.
Q: What is the shelf life of Fmoc-Pro-Pro-OH?
A: The shelf life of Fmoc-Pro-Pro-OH is typically 2 years when stored under appropriate conditions.

Conclusion

Fmoc-Pro-Pro-OH CAS:129223-22-9 is a versatile chemical compound widely used in the synthesis of peptides and proteins. This guide has provided a comprehensive overview of Fmoc-Pro-Pro-OH, including its product parameters, usage scenarios, case studies, solutions, expert advice, and frequently asked questions. By understanding the various aspects of Fmoc-Pro-Pro-OH, researchers and scientists can make informed decisions regarding its use in their projects.