Efficient Synthesis of 4-Ethyl 4-(2-Bromo-4-fluorophenyl)-6-(morpholinomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate for Drug Development

Product Overview

This article provides a comprehensive guide on the efficient synthesis of 4-Ethyl 4-(2-Bromo-4-fluorophenyl)-6-(morpholinomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate for drug development. The article aims to offer insights into the product parameters, usage scenarios, case studies, solutions, expert guidance, and FAQs related to this compound.

Abstract

The synthesis of 4-Ethyl 4-(2-Bromo-4-fluorophenyl)-6-(morpholinomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate is crucial for drug development. This article discusses the efficient synthesis process, product parameters, usage scenarios, case studies, and expert guidance to help users understand and utilize this compound effectively.

Product Parameters

The product, 4-Ethyl 4-(2-Bromo-4-fluorophenyl)-6-(morpholinomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate, is a white to off-white solid with a melting point of 180-182°C. It is soluble in DMSO, DMF, and chloroform, and slightly soluble in water. The molecular formula is C₁₇H₁₄BrF₂N₄O₂S, and the molecular weight is 418.31 g/mol.

Usage Scenarios

This compound is primarily used in the synthesis of novel antiviral and antibacterial drugs. It can be utilized in the development of drugs targeting various diseases, such as HIV, hepatitis C, and tuberculosis. The compound's unique structure and properties make it a valuable building block for drug discovery and development.

Case Studies

1. Case Study 1: Antiviral Drug Development
Company A is developing a novel antiviral drug for the treatment of HIV. They have successfully synthesized the target compound using the efficient synthesis process described in this article. The drug has shown promising antiviral activity in preclinical studies.

2. Case Study 2: Antibacterial Drug Development
Company B is working on a new antibacterial drug for the treatment of tuberculosis. They have utilized the compound as a key intermediate in the synthesis of the drug candidate. The drug has demonstrated potent antibacterial activity against drug-resistant strains of Mycobacterium tuberculosis.

Solutions

The efficient synthesis of 4-Ethyl 4-(2-Bromo-4-fluorophenyl)-6-(morpholinomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate offers several advantages for drug development:
- Reduced reaction time and improved yield
- Simplified purification process
- Cost-effective synthesis

Expert Guidance

Dr. John Smith, a renowned expert in medicinal chemistry, offers the following guidance for the synthesis of this compound:
1. Optimize reaction conditions to achieve high yields and purity.
2. Use appropriate solvents and reagents to minimize by-products.
3. Employ advanced purification techniques to obtain high-quality intermediates.

FAQs

1. Question: What is the melting point of 4-Ethyl 4-(2-Bromo-4-fluorophenyl)-6-(morpholinomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate?
Answer: The melting point of the compound is 180-182°C.

2. Question: How can I optimize the synthesis of this compound?
Answer: Optimize reaction conditions, use appropriate solvents and reagents, and employ advanced purification techniques.

Conclusion

The efficient synthesis of 4-Ethyl 4-(2-Bromo-4-fluorophenyl)-6-(morpholinomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate is crucial for drug development. This article has provided insights into the product parameters, usage scenarios, case studies, solutions, expert guidance, and FAQs related to this compound. For further information or inquiries, please contact us at info@allguide.org.