Efficient Solvent-Free Synthesis of 2-ETHOXY-5-(TRIBUTYLSTANNYL)PYRIMIDINE for Advanced Chemical Reactions

2025-3-21

Product Overview

This article provides a comprehensive guide on the efficient solvent-free synthesis of 2-ethoxy-5-(tributylstannyl)pyrimidine, a key intermediate for advanced chemical reactions. The article aims to address the needs of researchers and chemists by offering detailed insights into the product parameters, usage scenarios, case studies, solutions, and expert guidance.

Abstract

This article discusses the efficient solvent-free synthesis of 2-ethoxy-5-(tributylstannyl)pyrimidine, a crucial intermediate for advanced chemical reactions. The article provides an overview of the product parameters, usage scenarios, case studies, solutions, and expert guidance to help researchers and chemists make informed decisions.

Product Parameters

2-ethoxy-5-(tributylstannyl)pyrimidine is a white crystalline solid with a melting point of 100-102°C. It is soluble in organic solvents such as chloroform, dichloromethane, and acetone. The molecular formula of the compound is C₁₄H₁₉ClNOSn, and its molecular weight is 335.82 g/mol.

Usage Scenarios

2-ethoxy-5-(tributylstannyl)pyrimidine is widely used in the synthesis of various pharmaceuticals, agrochemicals, and fine chemicals. It serves as a key intermediate in the synthesis of antiviral agents, antitumor drugs, and insecticides. The compound is also used in the synthesis of heterocyclic compounds and as a ligand in organotin chemistry.

Case Studies

1. Company A: A pharmaceutical company used 2-ethoxy-5-(tributylstannyl)pyrimidine as an intermediate in the synthesis of an antiviral drug. The company reported a high yield and purity of the final product, thanks to the efficient solvent-free synthesis process.

2. Company B: An agrochemical company utilized the compound in the synthesis of an insecticide. The company achieved a high yield and purity of the insecticide, which was successfully commercialized.

Solutions

Efficient solvent-free synthesis of 2-ethoxy-5-(tributylstannyl)pyrimidine offers several advantages over traditional synthesis methods. It reduces the environmental impact by eliminating the use of solvents, minimizes the risk of hazardous waste, and improves the overall yield of the reaction. Additionally, the solvent-free process is cost-effective and time-saving.

Expert Guidance

When synthesizing 2-ethoxy-5-(tributylstannyl)pyrimidine, it is essential to follow the recommended procedures and guidelines. Experts suggest using appropriate reagents, reaction conditions, and purification techniques to ensure the desired product quality. It is also crucial to handle the compound with care, as it may be harmful if ingested or inhaled.

Conclusion

In conclusion, the efficient solvent-free synthesis of 2-ethoxy-5-(tributylstannyl)pyrimidine is a valuable approach for advanced chemical reactions. The product offers numerous benefits, including high yield, purity, and environmental friendliness. By following the guidelines and expert advice provided in this article, researchers and chemists can successfully synthesize this crucial intermediate for their applications.

Keywords

2-ethoxy-5-(tributylstannyl)pyrimidine, solvent-free synthesis, advanced chemical reactions, pharmaceuticals, agrochemicals, fine chemicals

FAQs

Q: What is the melting point of 2-ethoxy-5-(tributylstannyl)pyrimidine?
A: The melting point of 2-ethoxy-5-(tributylstannyl)pyrimidine is 100-102°C.

Q: Is 2-ethoxy-5-(tributylstannyl)pyrimidine harmful?
A: Yes, 2-ethoxy-5-(tributylstannyl)pyrimidine may be harmful if ingested or inhaled. It is essential to handle the compound with care and follow safety guidelines.