Efficient Synthesis Aid： N-Butyllithium CAS 109-72-8 for Lab Solutions

Efficient Synthesis Aid: N-Butyllithium CAS 109-72-8 for Lab Solutions

This comprehensive guide aims to provide an in-depth understanding of N-Butyllithium CAS 109-72-8, an essential reagent for laboratory synthesis. The article delves into the product parameters, usage scenarios, case studies, solutions, expert guidance, and frequently asked questions to ensure that users have a thorough understanding of this powerful synthesis aid.

Product Overview

N-Butyllithium CAS 109-72-8 is a highly reactive organolithium compound that plays a crucial role in organic synthesis. It is widely used in the preparation of alcohols, ethers, esters, and other organic compounds. This guide will help users understand the product's properties, applications, and best practices for its use in the laboratory.

Product Parameters

Here are the key parameters of N-Butyllithium CAS 109-72-8:

Usage Scenarios

N-Butyllithium CAS 109-72-8 is a versatile reagent that finds applications in various laboratory settings. Here are some common usage scenarios:

• Preparation of alcohols: N-Butyllithium can be used to synthesize alcohols from aldehydes, ketones, and carboxylic acids.
• Formation of ethers: It is employed in the synthesis of ethers from alcohols and alkyl halides.
• Production of esters: N-Butyllithium can be used to synthesize esters from carboxylic acids and alcohols.
• Other applications: It is also used in the synthesis of amides, nitriles, and other organic compounds.

Case Studies

Here are two case studies showcasing the use of N-Butyllithium CAS 109-72-8 in real-world applications:

Case Study 1: Synthesis of Ethyl Butyrate

Company A, a leading manufacturer of flavor and fragrance compounds, used N-Butyllithium CAS 109-72-8 to synthesize ethyl butyrate. The process involved reacting ethyl acetate with N-Butyllithium in a polar aprotic solvent. The resulting ethyl butyrate was used as a key intermediate in the production of a popular fruit flavor.

Case Study 2: Synthesis of 2-Butanol

Company B, a producer of pharmaceutical intermediates, employed N-Butyllithium CAS 109-72-8 to synthesize 2-butanol. The process involved reacting 2-butanone with N-Butyllithium in a polar aprotic solvent. The resulting 2-butanol was used as a key intermediate in the synthesis of a widely used pharmaceutical compound.

Solutions

When using N-Butyllithium CAS 109-72-8, it is essential to follow best practices to ensure safety and efficiency. Here are some solutions to consider:

• Use appropriate solvents: Polar aprotic solvents, such as diethyl ether or tetrahydrofuran, are commonly used to dissolve N-Butyllithium.
• Control reaction conditions: Maintain the reaction temperature and pressure within the recommended range to optimize yields and minimize side reactions.
• Handle with care: N-Butyllithium is highly reactive and can cause fires or explosions if not handled properly. Always wear appropriate personal protective equipment (PPE) and follow safety protocols.

Expert Guidance

For users seeking expert guidance on the use of N-Butyllithium CAS 109-72-8, it is advisable to consult with experienced chemists or refer to scientific literature. Here are some resources that can provide valuable insights:

• Journal articles: Search for peer-reviewed articles on the synthesis of organic compounds using N-Butyllithium.
• Books: Look for comprehensive organic chemistry textbooks that cover the use of organolithium reagents.
• Online forums: Join online communities of organic chemists to discuss best practices and share experiences.

Frequently Asked Questions (FQA)

Here are some frequently asked questions about N-Butyllithium CAS 109-72-8:

• Q: Is N-Butyllithium CAS 109-72-8 flammable?
• A: Yes, N-Butyllithium is highly flammable and should be handled with extreme caution.
• Q: What are the health hazards associated with N-Butyllithium CAS 109-72-8?
• A: N-Butyllithium can cause severe burns and other health issues upon contact with skin or inhalation of its vapors.
• Q: Can N-Butyllithium CAS 109-72-8 be used in water?
• A: No, N-Butyllithium is incompatible with water and should not be used in aqueous solutions.

Conclusion

N-Butyllithium CAS 109-72-8 is a powerful synthesis aid that plays a crucial role in organic chemistry. By understanding its properties, applications, and best practices for use, users can optimize their laboratory processes and achieve desired results. This guide has provided a comprehensive overview of N-Butyllithium CAS 109-72-8, including product parameters, usage scenarios, case studies, solutions, expert guidance, and frequently asked questions.

Keywords

N-Butyllithium CAS 109-72-8, synthesis aid, organic chemistry, reagent, laboratory, case studies, safety, best practices

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