Efficient Synthesis Aid： 4-(Trifluoromethyl)Pyridine-3-Borononic Acid Hydrate for Challenging Reactions

2025-3-21

Efficient Synthesis Aid: 4-(Trifluoromethyl)Pyridine-3-Borononic Acid Hydrate for Challenging Reactions

Efficient Synthesis Aid: 4-(Trifluoromethyl)Pyridine-3-Borononic Acid Hydrate is a cutting-edge product designed to facilitate challenging reactions in the field of organic synthesis. This guide aims to provide a comprehensive overview of the product, including its parameters, usage scenarios, case studies, solutions, and expert guidance. By the end of this article, readers will have a clear understanding of how this innovative aid can enhance their synthetic processes.

Product Overview

4-(Trifluoromethyl)Pyridine-3-Borononic Acid Hydrate is a versatile reagent that finds extensive application in the synthesis of complex organic molecules. It is a white crystalline solid that is highly soluble in polar organic solvents. The product is available in various purity levels, with the standard purity being 98%. The molecular formula of the hydrate is C₆H₄BF₃NO₃·H₂O, and its molecular weight is 197.9 g/mol.

Product Parameters

Parameter	Value
Purity	98%
Molecular Formula	C₆H₄BF₃NO₃·H₂O
Molecular Weight	197.9 g/mol
Appearance	White crystalline solid
Solubility	Highly soluble in polar organic solvents

Usage Scenarios

4-(Trifluoromethyl)Pyridine-3-Borononic Acid Hydrate is widely used in various challenging reactions, including:

As a nucleophilic boronic acid derivative in Suzuki coupling reactions
As a ligand in organometallic chemistry
As a building block in the synthesis of biologically active molecules

Case Studies

Here are two case studies showcasing the application of 4-(Trifluoromethyl)Pyridine-3-Borononic Acid Hydrate in challenging reactions:

Case Study 1: Synthesis of a Bioactive Molecule

Company A was facing difficulties in the synthesis of a bioactive molecule due to the presence of a challenging functional group. By incorporating 4-(Trifluoromethyl)Pyridine-3-Borononic Acid Hydrate into their synthetic pathway, they were able to successfully synthesize the molecule with high purity and yield.

Case Study 2: Suzuki Coupling Reaction

Company B was struggling to achieve a high yield in a Suzuki coupling reaction involving a difunctional boronic acid. By using 4-(Trifluoromethyl)Pyridine-3-Borononic Acid Hydrate as a nucleophilic boronic acid derivative, they achieved a yield of 90% in the reaction.

Solutions

4-(Trifluoromethyl)Pyridine-3-Borononic Acid Hydrate offers several solutions for challenging reactions:

Enhanced reactivity and selectivity in Suzuki coupling reactions
Improved yield and purity in the synthesis of bioactive molecules
Facilitated access to complex organic molecules

Expert Guidance

For optimal results, it is recommended to follow these guidelines when using 4-(Trifluoromethyl)Pyridine-3-Borononic Acid Hydrate:

Ensure the purity of the reagent is 98% or higher
Use appropriate solvents and reaction conditions
Monitor the reaction progress and optimize the reaction parameters

Conclusion

4-(Trifluoromethyl)Pyridine-3-Borononic Acid Hydrate is a valuable tool for overcoming challenges in organic synthesis. Its unique properties make it an excellent choice for a wide range of reactions, including Suzuki coupling, organometallic chemistry, and the synthesis of bioactive molecules. By following the guidelines provided in this guide, researchers can achieve successful outcomes in their synthetic endeavors.