Efficient Synthesis Aid： 6-Chloro-5-Methylpyridine-3-Boronic Acid for Advanced Organic Chemistry Solutions

Efficient Synthesis Aid: 6-Chloro-5-Methylpyridine-3-Boronic Acid for Advanced Organic Chemistry Solutions

Abstract

This article provides a comprehensive guide on the use of 6-Chloro-5-Methylpyridine-3-Boronic Acid as an efficient synthesis aid in advanced organic chemistry. It covers the product parameters, usage scenarios, case studies, solutions, expert guidance, and FAQs to help users understand and utilize this compound effectively.

1. Product Parameters

The 6-Chloro-5-Methylpyridine-3-Boronic Acid is a white crystalline solid with a melting point of 150-152°C. It is soluble in water, methanol, and dimethylformamide. The molecular formula is C₇H₆ClNO₂Br, and the molecular weight is 227.09 g/mol. The following table provides a detailed breakdown of its physical and chemical properties:

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2. Usage Scenarios

The 6-Chloro-5-Methylpyridine-3-Boronic Acid is widely used in the synthesis of various organic compounds, including heterocyclic compounds, pharmaceuticals, and agrochemicals. Some common usage scenarios include:

- Synthesis of pyridine derivatives
- Construction of heterocyclic rings
- Formation of boronic acid esters
- Cross-coupling reactions

3. Case Studies

Here are two case studies showcasing the use of 6-Chloro-5-Methylpyridine-3-Boronic Acid in organic synthesis:

**Case Study 1: Synthesis of Pyridine Derivatives**
A research team synthesized a series of pyridine derivatives using 6-Chloro-5-Methylpyridine-3-Boronic Acid as a key intermediate. The reaction involved a one-pot synthesis of pyridine derivatives from aldehydes and amines. The yield of the desired products was found to be 80-90%.

**Case Study 2: Construction of Heterocyclic Rings**
In another study, the 6-Chloro-5-Methylpyridine-3-Boronic Acid was used to construct a heterocyclic ring in a multicomponent reaction. The reaction involved the coupling of an aldehyde, an amine, and a boronic acid. The yield of the heterocyclic compound was 85%.

4. Solutions

The 6-Chloro-5-Methylpyridine-3-Boronic Acid offers several advantages in organic synthesis, making it an ideal choice for various applications:

- High purity and stability
- Easy to handle and store
- Compatible with various reaction conditions
- Cost-effective

5. Expert Guidance

To ensure the successful use of 6-Chloro-5-Methylpyridine-3-Boronic Acid in your organic synthesis, it is essential to follow expert guidance. Here are some tips:

- Use the appropriate solvent and reaction conditions
- Optimize the reaction parameters, such as temperature and time
- Monitor the reaction progress using appropriate analytical techniques
- Purify the product using suitable methods

6. FAQs

Below are some frequently asked questions about the 6-Chloro-5-Methylpyridine-3-Boronic Acid:

**Q1: What is the shelf life of 6-Chloro-5-Methylpyridine-3-Boronic Acid?**
A1: The shelf life of 6-Chloro-5-Methylpyridine-3-Boronic Acid is 2 years when stored in a cool, dry place.

**Q2: Can 6-Chloro-5-Methylpyridine-3-Boronic Acid be used in green chemistry?**
A2: Yes, 6-Chloro-5-Methylpyridine-3-Boronic Acid is a green chemistry-friendly compound due to its high purity and minimal environmental impact.

**Q3: What are the safety precautions while handling 6-Chloro-5-Methylpyridine-3-Boronic Acid?**
A3: Wear appropriate personal protective equipment, such as gloves and safety goggles, while handling 6-Chloro-5-Methylpyridine-3-Boronic Acid. Ensure proper ventilation in the laboratory.

Conclusion

In conclusion, the 6-Chloro-5-Methylpyridine-3-Boronic Acid is an efficient synthesis aid in advanced organic chemistry. Its high purity, stability, and compatibility with various reaction conditions make it an ideal choice for various applications. By following expert guidance and addressing common FAQs, users can effectively utilize this compound in their organic synthesis endeavors.

Keywords

6-Chloro-5-Methylpyridine-3-Boronic Acid, organic synthesis, heterocyclic compounds, pharmaceuticals, agrochemicals, synthesis aid, green chemistry, expert guidance, FAQs

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