Síntesis eficaz de 5-bromo-2-cloro-7H-pirrolo[2,3-d]pirimidina para soluciones de descubrimiento de fármacos

Resumen

This article provides a comprehensive guide on the efficient synthesis of 5-Bromo-2-Chloro-7H-Pyrrolo[2,3-d]Pyrimidine, a crucial compound for drug discovery solutions. It delves into the product parameters, usage scenarios, case studies, solutions, expert guidance, and FAQs to ensure a thorough understanding of the compound and its applications.

Parámetros del producto

The 5-Bromo-2-Chloro-7H-Pyrrolo[2,3-d]Pyrimidine is a pyrimidine derivative with a bromo and chloro substituents at the 5 and 2 positions, respectively. The molecular formula is C₆H₃BrClN₂O, and its molecular weight is 265.5 g/mol. The compound is typically a white to off-white solid with a melting point of 237-241°C. The following table provides a detailed breakdown of the product parameters:

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Escenarios de uso

The 5-Bromo-2-Chloro-7H-Pyrrolo[2,3-d]Pyrimidine is widely used in the synthesis of various pharmaceuticals, including antiviral, antibacterial, and antitumor agents. It is also employed in the development of agrochemicals and as a building block for the synthesis of other organic compounds. The following scenarios highlight the compound's applications:

1. **Antiviral Agents**: The compound is used in the synthesis of antiviral drugs targeting RNA viruses, such as HIV and influenza. Its ability to inhibit viral replication makes it a valuable tool in the fight against these diseases.

2. **Antibacterial Agents**: The compound is employed in the development of antibacterial drugs that target Gram-positive and Gram-negative bacteria. Its broad-spectrum activity makes it a promising candidate for combating antibiotic-resistant strains.

3. **Antitumor Agents**: The compound is used in the synthesis of antitumor drugs that target various types of cancer cells. Its ability to inhibit tumor growth and metastasis makes it a valuable tool in cancer research and treatment.

Casos prácticos

The following case studies showcase the applications of 5-Bromo-2-Chloro-7H-Pyrrolo[2,3-d]Pyrimidine in drug discovery:

1. **Antiviral Drug Development**: A research team at a pharmaceutical company synthesized a novel antiviral drug using 5-Bromo-2-Chloro-7H-Pyrrolo[2,3-d]Pyrimidine as a key intermediate. The drug demonstrated potent antiviral activity against HIV and influenza viruses in preclinical studies.

2. **Antibacterial Drug Development**: Another research team at a biotech company used the compound to synthesize a novel antibacterial drug targeting Gram-negative bacteria. The drug showed promising activity against antibiotic-resistant strains in in vitro and in vivo studies.

3. **Antitumor Drug Development**: A research group at a university synthesized a novel antitumor drug using 5-Bromo-2-Chloro-7H-Pyrrolo[2,3-d]Pyrimidine as a key intermediate. The drug exhibited potent antitumor activity against various types of cancer cells in preclinical studies.

Soluciones

The efficient synthesis of 5-Bromo-2-Chloro-7H-Pyrrolo[2,3-d]Pyrimidine offers several advantages in drug discovery:

1. **Cost-Effective**: The synthesis process is cost-effective, making the compound readily available for research and development purposes.

2. **High Purity**: The compound is synthesized with high purity, ensuring its suitability for various applications in drug discovery.

3. **Scalability**: The synthesis process is scalable, allowing for the production of large quantities of the compound for research and development purposes.

Orientación experta

To ensure the successful synthesis and application of 5-Bromo-2-Chloro-7H-Pyrrolo[2,3-d]Pyrimidine, it is essential to seek expert guidance. The following tips can help researchers and scientists:

1. **Optimize Reaction Conditions**: Carefully optimize reaction conditions, such as temperature, pressure, and solvent choice, to achieve the highest yield and purity of the compound.

2. **Use High-Quality Reagents**: Use high-quality reagents and starting materials to ensure the desired purity and quality of the final product.

3. **Stay Informed**: Keep up-to-date with the latest research and developments in the field of drug discovery to stay ahead of the competition.

Preguntas frecuentes

The following FAQs address common questions regarding the synthesis and application of 5-Bromo-2-Chloro-7H-Pyrrolo[2,3-d]Pyrimidine:

1. **What is the melting point of 5-Bromo-2-Chloro-7H-Pyrrolo[2,3-d]Pyrimidine?**
The melting point of 5-Bromo-2-Chloro-7H-Pyrrolo[2,3-d]Pyrimidine is 237-241°C.

2. **How is 5-Bromo-2-Chloro-7H-Pyrrolo[2,3-d]Pyrimidine synthesized?**
The compound is synthesized through a multi-step synthesis process involving various reagents and reaction conditions.

3. **What are the applications of 5-Bromo-2-Chloro-7H-Pyrrolo[2,3-d]Pyrimidine in drug discovery?**
The compound is used in the synthesis of antiviral, antibacterial, and antitumor agents, as well as agrochemicals and other organic compounds.

Conclusión

The efficient synthesis of 5-Bromo-2-Chloro-7H-Pyrrolo[2,3-d]Pyrimidine offers numerous benefits in drug discovery. Its versatile applications, cost-effectiveness, and high purity make it a valuable tool for researchers and scientists. By following expert guidance and staying informed about the latest research and developments, users can maximize the potential of this compound in their drug discovery endeavors.

Palabras clave

5-Bromo-2-Chloro-7H-Pyrrolo[2,3-d]Pyrimidine, drug discovery, synthesis, antiviral, antibacterial, antitumor, agrochemicals, organic compounds, research, development.

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