Ayuda a la síntesis eficiente： Ácido 2-cloro-6-isopropilpiridin-3-borónico para soluciones de química orgánica avanzada.

Efficient Synthesis Aid: 2-Chloro-6-isopropylpyridine-3-Boronic Acid for Advanced Organic Chemistry Solutions

Resumen

This article provides a comprehensive guide on the use of 2-Chloro-6-isopropylpyridine-3-boronic acid as an efficient synthesis aid in advanced organic chemistry. It covers the product parameters, usage scenarios, case studies, solutions, expert guidance, and FAQs to help users understand and utilize this compound effectively.

1. Parámetros del producto

The 2-Chloro-6-isopropylpyridine-3-boronic acid is a white to off-white crystalline solid with a melting point of 102-104°C. It is soluble in water, methanol, and ethanol, and has a molecular weight of 224.12 g/mol. The compound is highly reactive and should be handled with care.

1.1 Chemical Formula and Molecular Weight

The chemical formula of 2-Chloro-6-isopropylpyridine-3-boronic acid is C₉H₁₁ClBN₂O, and its molecular weight is 224.12 g/mol.

1.2 Physical Properties

The physical properties of 2-Chloro-6-isopropylpyridine-3-boronic acid are summarized in the following table:

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2. Escenarios de uso

2-Chloro-6-isopropylpyridine-3-boronic acid is widely used in the synthesis of various organic compounds, including heterocyclic compounds, pharmaceuticals, and agrochemicals. It is particularly useful in the following scenarios:

2.1 Synthesis of Heterocyclic Compounds

The compound is an excellent building block for the synthesis of heterocyclic compounds, such as pyridines, pyrimidines, and purines. It can be used in the formation of C-N and C-B bonds, which are crucial for the construction of these complex molecules.

2.2 Synthesis of Pharmaceuticals

The compound is a valuable intermediate in the synthesis of various pharmaceuticals, including antiviral, antibacterial, and antifungal agents. Its ability to form C-N and C-B bonds makes it an ideal choice for the construction of drug molecules.

2.3 Synthesis of Agrochemicals

2-Chloro-6-isopropylpyridine-3-boronic acid is also used in the synthesis of agrochemicals, such as herbicides, insecticides, and fungicides. Its reactivity and versatility make it a valuable tool for the development of new agrochemicals.

3. Casos prácticos

The following case studies demonstrate the use of 2-Chloro-6-isopropylpyridine-3-boronic acid in the synthesis of various organic compounds:

3.1 Synthesis of Pyridine Derivatives

A research group at the University of XYZ successfully synthesized pyridine derivatives using 2-Chloro-6-isopropylpyridine-3-boronic acid as a key intermediate. The reaction involved the formation of a C-N bond between the boronic acid group and an amine, followed by cyclization to yield the desired pyridine derivative.

3.2 Synthesis of Antiviral Agents

Another research group at the University of ABC used 2-Chloro-6-isopropylpyridine-3-boronic acid to synthesize a novel antiviral agent. The compound was converted into a boronic acid ester, which then reacted with a diol to form a cyclic boronate ester. This intermediate was further transformed into the antiviral agent through a series of reactions.

3.3 Synthesis of Herbicides

A company specializing in agrochemicals, XYZ Agrochemicals, utilized 2-Chloro-6-isopropylpyridine-3-boronic acid in the synthesis of a new herbicide. The compound was converted into a boronic acid ester, which then reacted with a phenol to form a boronic acid phenyl ester. This intermediate was used in the synthesis of the herbicide through a series of reactions.

4. Soluciones

To ensure the successful synthesis of organic compounds using 2-Chloro-6-isopropylpyridine-3-boronic acid, the following solutions are recommended:

4.1 Proper Handling and Storage

The compound should be handled with care, as it is highly reactive. It should be stored in a cool, dry place, away from direct sunlight and moisture.

4.2 Reaction Optimization

The reaction conditions, such as temperature, pressure, and solvent choice, should be optimized to achieve the highest yield and purity of the desired product.

4.3 Purification Techniques

Effective purification techniques, such as recrystallization, chromatography, and crystallization, should be employed to obtain the pure compound.

5. Orientación experta

For users seeking expert guidance on the use of 2-Chloro-6-isopropylpyridine-3-boronic acid, the following resources are recommended:

5.1 Scientific Journals

Users can refer to scientific journals, such as the Journal of Organic Chemistry and Tetrahedron, for the latest research and applications of the compound.

5.2 Online Forums and Discussion Groups

Online forums and discussion groups, such as the Organic Synthesis Community and the ACS Division of Organic Chemistry, provide a platform for users to share their experiences and seek advice from experts.

5.3 Manufacturer's Technical Support

Users can contact the manufacturer of 2-Chloro-6-isopropylpyridine-3-boronic acid for technical support and guidance on the use of the compound.

6. Preguntas frecuentes

The following FAQs address common questions regarding the use of 2-Chloro-6-isopropylpyridine-3-boronic acid:

6.1 What is the shelf life of 2-Chloro-6-isopropylpyridine-3-boronic acid?

La vida útil del compuesto suele ser de 2 años si se almacena en condiciones adecuadas.

6.2 Can 2-Chloro-6-isopropylpyridine-3-boronic acid be used in large-scale synthesis?

Yes, the compound can be used in large-scale synthesis, provided that the reaction conditions and purification techniques are optimized.

6.3 Are there any side effects or health hazards associated with the use of 2-Chloro-6-isopropylpyridine-3-boronic acid?

The compound is considered safe for use in laboratory settings when handled and stored properly. However, users should always wear appropriate personal protective equipment (PPE) and follow safety guidelines.

Conclusión

In conclusion, 2-Chloro-6-isopropylpyridine-3-boronic acid is a valuable synthesis aid in advanced organic chemistry. Its ability to form C-N and C-B bonds makes it an ideal choice for the synthesis of various organic compounds, including heterocyclic compounds, pharmaceuticals, and agrochemicals. By following the guidelines provided in this article, users can effectively utilize this compound in their research and development efforts.

Palabras clave

2-Chloro-6-isopropylpyridine-3-boronic acid, synthesis aid, organic chemistry, heterocyclic compounds, pharmaceuticals, agrochemicals, reaction optimization, purification techniques, expert guidance, FAQs.

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