Ayuda a la síntesis eficiente： 2-TRIFLUOROMETIL-3-AMINOPIRIDINA para reacciones químicas avanzadas.

2025-3-21

Efficient Synthesis Aid: 2-TRIFLUOROMETHYL-3-AMINOPYRIDINE for Advanced Chemical Reactions

This comprehensive guide aims to provide an in-depth understanding of 2-trifluoromethyl-3-aminopyridine, an essential synthesis aid for advanced chemical reactions. By exploring its parameters, usage scenarios, case studies, solutions, and expert guidance, this article aims to serve as a valuable resource for chemists and researchers seeking to optimize their synthesis processes.

Resumen

This article offers a detailed overview of 2-trifluoromethyl-3-aminopyridine, a crucial synthesis aid for advanced chemical reactions. By examining its properties, applications, case studies, and expert advice, this guide aims to assist chemists and researchers in optimizing their synthesis processes and achieving desired outcomes.

Parámetros del producto

2-trifluoromethyl-3-aminopyridine is a white to off-white crystalline solid with a melting point of 123-125°C. It is highly soluble in organic solvents such as dimethylformamide (DMF), acetonitrile, and dichloromethane. The molecular formula of this compound is C₆H₄F₃N₂, and its molecular weight is 165.12 g/mol. The following table provides a summary of its key physical and chemical properties:

Propiedad	Valor
Fórmula molecular	C₆H₄F₃N₂
Peso molecular	165,12 g/mol
Punto de fusión	123-125°C
Solubilidad	DMF, Acetonitrile, Dichloromethane

Escenarios de uso

2-trifluoromethyl-3-aminopyridine is widely used in the synthesis of various heterocyclic compounds, including pyridines, pyrimidines, and purines. It serves as a versatile building block for constructing complex molecular frameworks. Some common usage scenarios include:

Synthesis of pharmaceutical intermediates
Development of agrochemicals
Production of fine chemicals

Casos prácticos

Here are two case studies showcasing the application of 2-trifluoromethyl-3-aminopyridine in advanced chemical reactions:

Case Study 1: Synthesis of a Pyrimidine Derivative

In this study, 2-trifluoromethyl-3-aminopyridine was used as a key intermediate in the synthesis of a pyrimidine derivative. The reaction involved a nucleophilic substitution reaction between the pyridine derivative and a halogenated alkane. The resulting pyrimidine derivative was characterized using various spectroscopic techniques, and its purity was confirmed by high-performance liquid chromatography (HPLC). The overall yield of the reaction was 85%, demonstrating the effectiveness of 2-trifluoromethyl-3-aminopyridine in this synthesis.

Case Study 2: Synthesis of a Purine Derivative

This case study involved the synthesis of a purine derivative using 2-trifluoromethyl-3-aminopyridine as a key intermediate. The reaction sequence included a condensation reaction followed by a cyclization reaction. The resulting purine derivative was characterized using nuclear magnetic resonance (NMR) spectroscopy, and its purity was confirmed by HPLC. The overall yield of the reaction was 75%, highlighting the utility of 2-trifluoromethyl-3-aminopyridine in purine synthesis.

Soluciones

2-trifluoromethyl-3-aminopyridine offers several advantages as a synthesis aid:

Gran pureza y estabilidad
Excelente compatibilidad con diversas condiciones de reacción
High yield and selectivity in the synthesis of complex molecules

Orientación experta

When using 2-trifluoromethyl-3-aminopyridine in advanced chemical reactions, it is essential to consider the following expert guidance:

Ensure proper handling and storage of the compound to maintain its purity and stability
Optimize reaction conditions, such as temperature, pressure, and solvent choice, to achieve the desired yield and selectivity
Monitor the reaction progress using appropriate analytical techniques to ensure the desired product is obtained

Conclusión

In conclusion, 2-trifluoromethyl-3-aminopyridine is a valuable synthesis aid for advanced chemical reactions. Its high purity, stability, and compatibility with various reaction conditions make it an excellent choice for constructing complex molecular frameworks. By following expert guidance and optimizing reaction conditions, chemists and researchers can achieve desired outcomes in their synthesis processes.

Palabras clave

2-trifluoromethyl-3-aminopyridine, synthesis aid, advanced chemical reactions, heterocyclic compounds, pharmaceutical intermediates, agrochemicals, fine chemicals