Optimize Peptide Synthesis with H-Gln(Trt)-OH (CAS 102747-84-2) for Enhanced Bioactivity

2025-3-21

Optimize Peptide Synthesis with H-Gln(Trt)-OH (CAS 102747-84-2) for Enhanced Bioactivity

Peptide synthesis is a crucial process in the pharmaceutical and biotechnology industries, as it allows for the creation of bioactive molecules with specific properties. This guide aims to provide a comprehensive overview of using H-Gln(Trt)-OH (CAS 102747-84-2) to optimize peptide synthesis, focusing on its parameters, usage scenarios, case studies, solutions, and expert guidance.

Visão geral do produto

H-Gln(Trt)-OH (CAS 102747-84-2) is a synthetic amino acid derivative commonly used in peptide synthesis. It serves as a protecting group for the amino group of glutamine (Gln) during the synthesis process. This protecting group enhances the stability and purity of the final peptide product, leading to improved bioactivity.

Parâmetros do produto

Here are the key parameters of H-Gln(Trt)-OH (CAS 102747-84-2):

Parâmetro	Valor
Nome químico	2-Aminopropionic acid, N-(tert-butyloxycarbonyl)-L-glutamine
Fórmula	C₁₀H₁₉N₃O₄
Peso molecular	237.28 g/mol
Aparência	Pó cristalino branco a esbranquiçado

Cenários de utilização

H-Gln(Trt)-OH (CAS 102747-84-2) is widely used in various applications, including:

Pharmaceutical research and development: Synthesis of bioactive peptides for drug discovery and development.
Biotechnology: Production of recombinant proteins and enzymes.
Food industry: Development of flavor enhancers and food additives.

Estudos de caso

Here are two case studies showcasing the use of H-Gln(Trt)-OH (CAS 102747-84-2) in peptide synthesis:

Case Study 1: Synthesis of a Bioactive Peptide for Pain Relief

Company A, a pharmaceutical company specializing in pain management, aimed to develop a novel bioactive peptide for pain relief. They used H-Gln(Trt)-OH (CAS 102747-84-2) as a protecting group during the synthesis process. The resulting peptide demonstrated significant pain-relieving activity in preclinical studies, leading to the initiation of clinical trials.

Case Study 2: Production of a Recombinant Enzyme

Company B, a biotechnology company, sought to produce a recombinant enzyme for industrial applications. They employed H-Gln(Trt)-OH (CAS 102747-84-2) in the synthesis of the enzyme's peptide chain. The resulting recombinant enzyme exhibited high catalytic activity and stability, making it suitable for large-scale production.

Soluções

Optimizing peptide synthesis with H-Gln(Trt)-OH (CAS 102747-84-2) offers several benefits:

Improved purity: The protecting group enhances the stability of the amino group, leading to higher purity of the final peptide product.
Enhanced bioactivity: The optimized synthesis process results in peptides with improved bioactivity, making them more effective in therapeutic applications.
Reduced synthesis time: The protecting group facilitates the synthesis process, reducing the overall time required for peptide production.

Orientação especializada

When using H-Gln(Trt)-OH (CAS 102747-84-2) for peptide synthesis, it is essential to follow expert guidance to ensure optimal results. Here are some key points to consider:

Choose the appropriate protecting group: Select a protecting group that is compatible with the specific amino acid sequence and reaction conditions.
Optimize reaction conditions: Adjust reaction temperature, pH, and time to achieve the best results.
Monitor the synthesis process: Regularly analyze the reaction progress to ensure the desired product is obtained.

Conclusão

In conclusion, H-Gln(Trt)-OH (CAS 102747-84-2) is a valuable tool for optimizing peptide synthesis, leading to improved purity, bioactivity, and efficiency. By following expert guidance and considering the specific requirements of the synthesis process, researchers and manufacturers can achieve optimal results in the production of bioactive peptides.