Auxiliar de Síntese Eficiente: Ácido 2-Bromo-3-Cloropiridina-4-Borónico para Reacções Quimio-Selectivas

2025-3-21

Efficient Synthesis Aid: 2-Bromo-3-Chloropyridine-4-Boronic Acid for Chemo Selective Reactions

Resumo

This article provides a comprehensive guide on the use of 2-Bromo-3-Chloropyridine-4-boronic acid as an efficient synthesis aid for chemo selective reactions. It covers the product parameters, usage scenarios, case studies, solutions, expert guidance, and FAQs to help users understand and utilize this compound effectively.

1. Parâmetros do produto

The 2-Bromo-3-Chloropyridine-4-boronic acid is a white to off-white crystalline solid with a melting point of 135-137°C. It is soluble in water, methanol, and dimethylformamide (DMF). The molecular formula is C6H3BrClBO3 and the molecular weight is 265.39 g/mol. The following table provides a detailed breakdown of its physical and chemical properties.

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Imóveis	Descrição
Aparência	Sólido cristalino branco a esbranquiçado
Ponto de fusão	135-137°C
Solubilidade	Water, methanol, DMF
Fórmula molecular	C6H3BrClBO3
Peso molecular	265.39 g/mol

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2. Cenários de utilização

2-Bromo-3-Chloropyridine-4-boronic acid is widely used in the synthesis of heterocyclic compounds, pharmaceuticals, and agrochemicals. It is particularly useful in chemo selective reactions, where it acts as a versatile synthetic aid. The following scenarios highlight its applications:

1. Synthesis of Heterocyclic Compounds

2-Bromo-3-Chloropyridine-4-boronic acid is used in the synthesis of various heterocyclic compounds, such as pyridines, pyrimidines, and purines. It facilitates the formation of C-N and C-O bonds, enabling the construction of complex molecular frameworks.

2. Synthesis of Pharmaceuticals

The compound is employed in the synthesis of pharmaceuticals, including antiviral, antibacterial, and antitumor agents. Its chemo selectivity allows for the targeted modification of specific functional groups, leading to the development of novel therapeutic agents.

3. Synthesis of Agrochemicals

2-Bromo-3-Chloropyridine-4-boronic acid is used in the synthesis of agrochemicals, such as herbicides and insecticides. Its chemo selectivity ensures the efficient construction of the desired molecular structure, minimizing the formation of by-products.

3. Estudos de caso

The following case studies showcase the use of 2-Bromo-3-Chloropyridine-4-boronic acid in real-world applications:

1. Synthesis of a Pyrimidine Derivative

A research team synthesized a pyrimidine derivative using 2-Bromo-3-Chloropyridine-4-boronic acid as a chemo selective reagent. The reaction proceeded with high yield and selectivity, demonstrating the compound's effectiveness in constructing complex molecular frameworks.

2. Synthesis of an Antiviral Agent

A pharmaceutical company utilized 2-Bromo-3-Chloropyridine-4-boronic acid in the synthesis of an antiviral agent. The compound facilitated the formation of a crucial functional group, leading to the development of a novel therapeutic agent with improved efficacy.

3. Synthesis of an Herbicide

An agrochemical company employed 2-Bromo-3-Chloropyridine-4-boronic acid in the synthesis of a herbicide. The compound's chemo selectivity ensured the efficient construction of the desired molecular structure, resulting in a high-yielding and environmentally friendly herbicide.

4. Soluções

To maximize the efficiency and selectivity of 2-Bromo-3-Chloropyridine-4-boronic acid in chemo selective reactions, the following solutions are recommended:

1. Optimal Reaction Conditions

Carefully optimize the reaction conditions, including temperature, pressure, and solvent choice, to achieve the highest yield and selectivity.

2. Catalyst Selection

Select an appropriate catalyst to enhance the reaction rate and minimize side reactions. Consider factors such as catalyst stability, reactivity, and compatibility with the reaction system.

3. Scale-Up Considerations

When scaling up the reaction, ensure that the chosen reaction conditions and equipment are suitable for large-scale production. This includes considering factors such as heat transfer, mixing efficiency, and safety.

5. Orientação especializada

For expert guidance on the use of 2-Bromo-3-Chloropyridine-4-boronic acid in chemo selective reactions, consult the following resources:

1. Scientific Journals

Review scientific journals that publish research on the synthesis of heterocyclic compounds, pharmaceuticals, and agrochemicals. These publications often provide valuable insights into the use of 2-Bromo-3-Chloropyridine-4-boronic acid and its applications.

2. Technical Databases

Access technical databases that contain information on chemical compounds, reaction mechanisms, and synthesis methods. These databases can help you identify suitable reaction conditions and catalysts for your specific application.

3. Industry Experts

Consult industry experts who have experience in the synthesis of heterocyclic compounds, pharmaceuticals, and agrochemicals. They can provide valuable advice on the use of 2-Bromo-3-Chloropyridine-4-boronic acid and its applications in your field.

6. Perguntas frequentes

The following FAQs address common questions regarding the use of 2-Bromo-3-Chloropyridine-4-boronic acid:

1. What is the purpose of 2-Bromo-3-Chloropyridine-4-boronic acid in chemo selective reactions?

2-Bromo-3-Chloropyridine-4-boronic acid acts as a chemo selective reagent, facilitating the formation of specific functional groups and minimizing side reactions.

2. How does 2-Bromo-3-Chloropyridine-4-boronic acid differ from other boronic acids?

2-Bromo-3-Chloropyridine-4-boronic acid possesses unique chemo selectivity, making it suitable for specific synthetic transformations that other boronic acids may not facilitate.

3. What are the optimal reaction conditions for using 2-Bromo-3-Chloropyridine-4-boronic acid?

Optimal reaction conditions vary depending on the specific application. However, factors such as temperature, pressure, and solvent choice should be carefully optimized to achieve the highest yield and selectivity.

Conclusão

In conclusion, 2-Bromo-3-Chloropyridine-4-boronic acid is an efficient synthesis aid for chemo selective reactions. Its unique chemo selectivity, versatility, and ease of use make it a valuable tool in the synthesis of heterocyclic compounds, pharmaceuticals, and agrochemicals. By following the guidelines provided in this article, users can effectively utilize this compound in their research and development efforts.

Palavras-chave

2-Bromo-3-Chloropyridine-4-boronic acid, chemo selective reactions, synthesis aid, heterocyclic compounds, pharmaceuticals, agrochemicals, reaction conditions, catalyst selection, scale-up, expert guidance, FAQs.