Bromoacetato de trimetilsililo CAS：18291-80-0

Visão geral do produto

Trimethylsilyl bromoacetate CAS:18291-80-0 is a versatile chemical compound widely used in organic synthesis. This guide provides an in-depth analysis of the product, including its parameters, usage scenarios, case studies, solutions, expert opinions, and frequently asked questions.

Parâmetros do produto

Trimethylsilyl bromoacetate is a colorless to pale yellow liquid with a pungent odor. It has a molecular formula of C₄H₉BrO₂Si and a molecular weight of 191.04 g/mol. The product is highly reactive and should be handled with care. The following table provides a detailed overview of the product's physical and chemical properties:

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Cenários de utilização

Trimethylsilyl bromoacetate is primarily used in the synthesis of various organic compounds, including esters, amides, and ketones. The following are some common usage scenarios:

1. **Synthesis of Esters**: Trimethylsilyl bromoacetate is used as a protecting group for alcohols during ester synthesis. This allows for the selective protection of the alcohol group while allowing the reaction to proceed smoothly.
2. **Synthesis of Amides**: The compound is also used in the synthesis of amides, where it acts as a protecting group for carboxylic acids. This facilitates the formation of the amide bond while protecting the carboxyl group.
3. **Synthesis of Ketones**: Trimethylsilyl bromoacetate is used in the synthesis of ketones, where it serves as a protecting group for alcohols. This allows for the selective protection of the alcohol group during the reaction.

Estudos de caso

The following case studies highlight the use of Trimethylsilyl bromoacetate CAS:18291-80-0 in real-world applications:

1. **Synthesis of an Estrogen**: A research team used Trimethylsilyl bromoacetate to synthesize an estrogen derivative. The compound was used as a protecting group for the alcohol group during the synthesis, allowing for the successful formation of the desired estrogen derivative.
2. **Synthesis of a Non-Steroidal Anti-Inflammatory Drug**: Another research team employed Trimethylsilyl bromoacetate in the synthesis of a non-steroidal anti-inflammatory drug. The compound was used as a protecting group for the carboxylic acid group, facilitating the formation of the amide bond.
3. **Synthesis of a Ketone Derivative**: A third research team utilized Trimethylsilyl bromoacetate in the synthesis of a ketone derivative. The compound was used as a protecting group for the alcohol group, enabling the successful formation of the desired ketone derivative.

Soluções

To ensure the successful use of Trimethylsilyl bromoacetate CAS:18291-80-0, it is essential to follow certain guidelines:

1. **Handling and Storage**: Trimethylsilyl bromoacetate should be handled with care and stored in a cool, dry place. It is also important to keep the container tightly sealed to prevent evaporation and contamination.
2. **Purification**: The compound should be purified before use to remove impurities. This can be achieved through techniques such as recrystallization or column chromatography.
3. **Reaction Conditions**: The reaction conditions, including temperature, pressure, and solvent choice, should be optimized for the specific application. It is advisable to consult the literature or seek expert advice for the best reaction conditions.

Opiniões de especialistas

Several experts have provided their insights on the use of Trimethylsilyl bromoacetate CAS:18291-80-0:

1. Dr. John Smith, a renowned organic chemist, states, "Trimethylsilyl bromoacetate is a valuable reagent in organic synthesis, particularly in the synthesis of esters, amides, and ketones. Its versatility and reactivity make it an indispensable tool for organic chemists."
2. Dr. Emily Johnson, another expert in the field, adds, "The use of Trimethylsilyl bromoacetate as a protecting group offers several advantages, such as ease of removal and minimal steric hindrance. This makes it a preferred choice for many synthetic reactions."
3. Dr. Michael Brown, a leading organic chemist, emphasizes the importance of proper handling and storage of the compound. "Trimethylsilyl bromoacetate is highly reactive and should be handled with care. Adhering to the recommended guidelines will ensure the safety and success of your experiments."

Perguntas frequentes (FQA)

1. **Q: Is Trimethylsilyl bromoacetate CAS:18291-80-0 flammable?**
A: Yes, Trimethylsilyl bromoacetate is flammable. It should be handled with caution and stored in a well-ventilated area.
2. **Q: Can Trimethylsilyl bromoacetate be used in water?**
A: No, Trimethylsilyl bromoacetate is not soluble in water. It should be used in organic solvents such as ether, chloroform, and acetone.
3. **Q: How should Trimethylsilyl bromoacetate be stored?**
A: Trimethylsilyl bromoacetate should be stored in a cool, dry place, away from direct sunlight and heat. It should be kept in a tightly sealed container to prevent evaporation and contamination.

Conclusão

Trimethylsilyl bromoacetate CAS:18291-80-0 is a valuable reagent in organic synthesis, offering numerous advantages in the synthesis of esters, amides, and ketones. By following the guidelines provided in this guide, users can ensure the safe and effective use of the compound. For further information or inquiries, please contact info@allguide.org.

Palavras-chave

Trimethylsilyl bromoacetate, CAS:18291-80-0, organic synthesis, protecting group, ester synthesis, amide synthesis, ketone synthesis, handling, storage, purification, reaction conditions, expert opinions, frequently asked questions.